# US 7,407,753 B2 · Methods, kits and pharmaceutical compositions for diagnosing, delaying onset of, preventing and/or treating osteoporosis

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- Number: US 7,407,753 B2
- Document ID: US7407753B2
- Status: Granted
- Kind: B2
- Application number: 10/851,667
- Filed: 2004-05-24
- Published: 2005-11-24
- Granted: 2008-08-05
- Earliest claimed: 2004-05-24
- Assignees: Yissum Research Development Company of the HebrewUniversityofJerusalem; Institut National de la Sante et de la Recherche Medicale; Andreas Zimmer; Meliha Karsak
- Inventors: Andreas Zimmer; Meliha Karsak; Marie-Christine De Vernejoul; Itai Bab; Esther Shohami; Raphael Mechoulam
- Web page: https://patentgrep.com/patent/US7407753B2

## CPC

- C07K 16/18: against material from animals or humans
- C12Q 1/6886: for cancer (immunoassay for cancer G01N33/575)
- C12Q 2600/16: Primer sets for multiplex assays
- C12Q 2600/172: Haplotypes
- C07K: PEPTIDES (peptides in foodstuffs A23; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs A23J; preparations for medicinal purposes A61K; peptides containing beta-lactam rings C07D; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, C07D; ergot alkaloids of the cyclic peptide type C07D519/02; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids C08G69/00; macromolecular products derived from proteins C08H1/00; preparation of glue or gelatine C09H; single cell proteins, enzymes C12N; genetic engineering processes for obtaining peptides C12N15/00; compositions for measuring or testing processes involving enzymes C12Q; investigation or analysis of biological material G01N33/00)
- C12Q: MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS (immunoassay G01N33/53); COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES

## Abstract

The present invention uncovers a highly significant association of SNPs in the CNR2 locus, encoding the cannabinoid receptor 2 protein, with osteoporosis. Methods and kits for determining predisposition to osteoporosis, improving diagnosis in individuals suspected of having osteoporosis are provided. Also provided a method of identifying a putative osteoporosis-causing genetic mutation in a subject.

## Claims

### Claim 1

A method of determining if a human individual is predisposed to osteoporosis, the method comprising: obtaining a nucleic acid sample from said human individual and analyzing said nucleic acid sample to determine the identity of a polymorphic variant at position 26 of SEQ ID NO: 14; wherein the presence of a guanine at position 26 of SEQ ID No: 14 is indicative of a predisposition to osteoporosis.