# US 7,407,673 B2 · Radioactive magnetic fluids for treatment or diagnosis of cancer, process for preparing them and use thereof

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- Number: US 7,407,673 B2
- Document ID: US7407673B2
- Status: Granted
- Kind: B2
- Application number: 10/635,615
- Filed: 2003-08-07
- Published: 2005-01-27
- Granted: 2008-08-05
- Earliest claimed: 2003-07-11
- Assignees: Chong-Oh Kim
- Inventors: Chong-Oh Kim; Jong-Hee Kim; Yuqiang Huang; Sang-Im Park
- Web page: https://patentgrep.com/patent/US7407673B2

## CPC

- A61K 51/1255: {Granulates, agglomerates, microspheres}
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)

## Abstract

The present invention relates to radioactive magnetic fluids, process for preparing them and use thereof. Particularly, the present invention relates to the radioactive magnetic fluids for treatment or diagnosis of cancer, process for preparing them and use thereof. The radioactive magnetic fluids of the present invention include the component of Cu2+ which radiates a β-ray and γ-ray. The β radiation can effectively kill the tumor cells. Since the γ radiation are easily imaged with γ-camera, the magnetic fluids can be gathered to the treatment site with the radiograph under external magnetic field. Therefore, the radioactive magnetic fluids of the present invention can be used for treatment of cancer with minimal side effects. Also, the tightly bonded decanoic acid and nonanoic acid layer of the present invention not only increase particle-particle repulsion but also take hydrophilicity, to disperse homogeneously and stably the magnetic nanoparticles in water. Also, carboxylic acid of the surfactant is exposed to outside, to prevent the magnetic nanoparticles from being oxidized by air. Therefore, the radioactive magnetic fluids can be used as therapeutic drug or diagnostic reagent for cancer.

## Claims

### Claim 1

A radioactive magnetic fluid comprising: magnetic nanoparticles of CuxFe1-xO·Fe2O3; and surfactants coated onto the surface of the magnetic nanoparticles, wherein x value is between 0.1 and 0.4 and a component of copper in the magnetic nanoparticles of CuxFe1-xO·Fe2O3 is a radioactive copper.

### Claim 2 (depends on 1)

The radioactive magnetic fluids according to claim 1, wherein the magnetic nanoparticles of CuxFe1-xO·Fe2O3 are obtained by coprecipitating components of Fe2+ and Fe3+ with a component of radioactive Cu2+ under presence of a precipitator.

### Claim 3 (depends on 1)

The radioactive magnetic fluids according to claim 1, wherein the surfactants comprise a first surfactant coated onto the surface of the magnetic nanoparticles, the first surfactant being decanoic acid, and a second surfactant coated onto the first-coated magnetic nanoparticles, the second surfactant being nonanoic acid.

### Claim 4 (depends on 1)

A process for preparing the radioactive magnetic fluids of claim 1, which comprises:
1) preparing the magnetic nanoparticles of CuxFe1-xO·Fe2O3 by coprecipitating the components of Fe2+ and Fe3+ with the component of radioactive Cu2+ under presence of a precipitator;
2) first coating the magnetic nanoparticles with decanoic acid; and
3) second coating the first-coated magnetic nanoparticles with nonanoic acid.

### Claim 5 (depends on 4)

The process according to claim 4, wherein the precipitator is sodium hydroxide.

### Claim 6 (depends on 4)

The process according to claim 4, wherein the mole ratio of (Cu2++Fe2+) to Fe3+ is within range of (1.1˜1.4):2.

### Claim 7 (depends on 1)

A therapeutic drug for cancer containing the radioactive magnetic fluid according to claim 1.

### Claim 8 (depends on 1)

A diagnostic reagent for cancer containing the radioactive magnetic fluid according to claim 1.