# US 7,407,647 B2 · Organic radiographic contrasting agents for medical devices

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- Number: US 7,407,647 B2
- Document ID: US7407647B2
- Status: Granted
- Kind: B2
- Application number: 11/296,606
- Filed: 2005-12-07
- Published: 2007-06-07
- Granted: 2008-08-05
- Earliest claimed: 2005-12-07
- Assignees: Cordis Corporation
- Inventors: Jonathon Z. Zhao
- Web page: https://patentgrep.com/patent/US7407647B2

## CPC

- A61K 49/0442: {Polymeric X-ray contrast-enhancing agent comprising a halogenated group}
- A61K 49/0433: {containing an organic halogenated X-ray contrast-enhancing agent}
- A61K 49/0447: {Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound}
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)

## Abstract

The present invention discloses an organic radiographic contrasting agent containing an aliphatic or alicyclic backbone and multiple halogen-substituted aromatic groups. Each of the halogen-substituted aromatic groups in the radiographic contrasting agent is substituted with at least three halogen atoms and is covalently attached to the aliphatic or alicyclic backbone. The present invention also discloses a radio-opaque polymeric material comprising the radiographic contrasting agent and at least one polymer. The radiographic contrasting agent is physically admixed with the at least one polymer or physically embedded or dispersed in the at least one polymer. The radio-opaque polymeric material provides enhanced contrasting intensity in radiographic imaging. The radio-opaque polymeric material can be applied on at least a portion of one surface of a medical device. The radio-opaque polymeric material can also be used to construct a medical device, a component thereof, or a portion of a component thereof.

## Claims

### Claim 1

A radiographic contrast agent, having the following structure:

### Claim 2

A radiographic contrast agent, having the following structure: