# US 7,407,645 B2 · Bioconjugates of metal complexes of nitrogen-containing macrocyclic ligands

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- Number: US 7,407,645 B2
- Document ID: US7407645B2
- Status: Granted
- Kind: B2
- Application number: 10/737,486
- Filed: 2003-12-16
- Published: 2004-07-08
- Granted: 2008-08-05
- Earliest claimed: 1995-08-17
- Assignees: MetaPhore Pharmaceuticals, Inc.
- Inventors: William L. Neumann; Dennis P. Riley; Randy H. Weiss; Susan L. Henke; Patrick J Lennon; Karl W. Aston
- Web page: https://patentgrep.com/patent/US7407645B2

## CPC

- A61K 49/0002: {General or multifunctional contrast agents, e.g. chelated agents}
- A61K 49/106: {the complex-forming compound being cyclic, e.g. DOTA}
- A61K 51/0482: {chelates from cyclic ligands, e.g. DOTA}
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)

## Abstract

The present invention is directed to bioconjugates of complexes represented by the formula: wherein R, R′, R1, R′1, R2, R′2, R3, R′3, R4, R′4, R5, R′5, R6, R′6, R7, R′7, R8, R′8, R9, R′9, M, X, Y, Z and n are defined herein for use as contrast agents in diagnostic imaging.

## Claims

### Claim 1

A compound which is complex represented by the
wherein said biomolecule is independently selected from the group consisting of steroids, carbohydrates, fatty acids, amino acids, peptides, proteins, antibodies, vitamins, lipids, phospholipds, phosphates, phosphonates, nucleic acids, enzyme substrates, enzyme inhibitors and enzyme receptor substrates.

### Claim 2 (depends on 1)

Compound of claim 1 wherein the biomolecule is a carbohydrate.

### Claim 3 (depends on 2)

Compound of claim 2 wherein the biomolecule is a polysaccharide.

### Claim 4 (depends on 3)

Compound of claim 3 wherein the biomolecule is a glycosaminoglycan.

### Claim 5 (depends on 3)

Compound of claim 3 wherein the biomolecule is hyaluronic acid.