# US 7,407,576 B2 · Separating agent for an optical enantiomeric isomer

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- Number: US 7,407,576 B2
- Document ID: US7407576B2
- Status: Granted
- Kind: B2
- Application number: 10/533,217
- Filed: 2003-11-13
- Published: 2006-01-19
- Granted: 2008-08-05
- Earliest claimed: 2002-11-19
- Assignees: Daicel Chemical Industries, Ltd.
- Inventors: Shinsuke Suzuki; Atsushi Onishi; Kazumi Suzuki
- Web page: https://patentgrep.com/patent/US7407576B2

## CPC

- B01J 20/3272: {Polymers obtained by reactions otherwise than involving only carbon to carbon unsaturated bonds}
- B01D 15/3833: {Chiral chromatography}
- B01J 20/103: {comprising silica}
- B01J 20/28004: {Sorbent size or size distribution, e.g. particle size}
- B01J 20/28078: {Pore diameter}
- B01J 20/286: Phases chemically bonded to a substrate, e.g. to silica or to polymers
- B01J 20/29: Chiral phases
- B01J 20/3204: {Inorganic carriers, supports or substrates}
- B01J 20/3259: {comprising at least two different types of heteroatoms selected from nitrogen, oxygen or sulfur with at least one silicon atom}
- B01J 20/3274: {Proteins, nucleic acids, polysaccharides, antibodies or antigens}
- B01J 20/328: {Polymers on the carrier being further modified}
- B01J 2220/54: Sorbents specially adapted for analytical or investigative chromatography
- B01J 2220/58: Use in a single column
- B01J: CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01D: SEPARATION (separating solids from solids by wet methods B03B, B03D; by pneumatic jigs or tables B03B; by other dry methods B07; magnetic or electrostatic separation of solid materials from solid materials or fluids, separation by high-voltage electric fields B03C; centrifuges, vortex apparatus B04; presses per se for squeezing-out liquid from liquid-containing material B30B9/02; treatment of water C02F, e.g. softening by ion-exchange C02F1/42; {arrangements of air intake cleaners in gas turbine plants F02C7/05} ; arrangements or mounting of filters in air-conditioning, air-humidification or ventilation F24F13/28)

## Abstract

The present invention is to provide a method of producing a separating agent for an enantiomeric isomer having a high optical resolution power together with sufficient solvent resistance. That is, a method of producing a separating agent for an enantiomeric isomer comprising the steps of allowing the porous carrier to carry the optically active polymer compound by bringing the porous carrier into contact with a dope of the optically active polymer compound and exposing a product to radiation.

## Claims

### Claim 1

A separating agent for an enantiomeric isomer, comprising amylose tris [(S)-phenylethylcarbamate] an optically active polymer compound carried on a porous carrier, the optically active polymer compound having been insolubilized through exposure to 50-500 kGy of γ-ray radiation.

### Claim 2 (depends on 1)

The separating agent for an enantiomeric isomer according to claim 1, wherein the optically active polymer compound contains no polymerizable unsaturated group.

### Claim 3 (depends on 1)

The separating agent for an enantiomeric isomer according to claim 1, wherein the porous carrier is silica gel.