# US 7,407,542 B2 · Pasty or liquid multiple constituent compositions for injectable calcium phosphate cements

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- Number: US 7,407,542 B2
- Document ID: US7407542B2
- Status: Granted
- Kind: B2
- Application number: 10/491,189
- Filed: 2002-10-01
- Published: 2004-12-09
- Granted: 2008-08-05
- Earliest claimed: 2001-11-14
- Assignees: Ecole Polytechnique Federale de Lausanne-Service des Relations Industrielles
- Inventors: Jacques Lemaitre; Christian Pittet; David Brendlen
- Web page: https://patentgrep.com/patent/US7407542B2

## CPC

- A61L 24/02: containing inorganic materials
- A61K 6/838: Phosphorus compounds, e.g. apatite
- A61K 6/864: Phosphate cements (apatite A61K6/838)
- A61L 2430/02: for reconstruction of bones; weight-bearing implants
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)

## Abstract

The invention concerns injectable bone filling cements, in particular hydraulic calcium phosphate cements, the latter being prepared from at least two initial liquid or pasty constituents comprising each a species reactive in solution or in suspension, the solidification process being initiated when said constituents are being mixed.

## Claims

### Claim 1

A process for making a calcium phosphate cement from a reaction of at least two pasty starting constituents which are mixed together in a mixing step, each of said constituents containing at least one reactive entity; said process also comprising a degassing step which is carried out on each constituent before the mixing step.

### Claim 2 (depends on 1)

The process as claimed in claim 1, wherein the pasty constituents comprise aqueous solutions of at least one of the following compounds: di-sodium di-hydrogen pyrophosphate (Na2H2P2O7), di-sodium hydrogen orthophosphate (Na2HPO4), and orthophosphoric acid (H3PO4).

### Claim 3 (depends on 1)

The process as claimed in claim 1, wherein the calcium phosphate cement is DCPD (dicalcium phosphate dihydrate) and the reactive entities are β-TCP (β-tricalcium phosphate) and MCPM (monocalcium phosphate monohydrate).

### Claim 4 (depends on 1)

The process as claimed in claim 1, wherein the calcium phosphate cement is OHAP (hydroxyapatite) and the reactive entities are TTCP (tetracalcium phosphate monoxide) and DCPA (anhydrous dicalcium phosphate).

### Claim 5 (depends on 1)

The process as claimed in claim 1, wherein the calcium phosphate cement is OHAP (hydroxyapatite) and the reactive entities are α-TCP (α-tricalcium phosphate), MCPM (monocalcium phosphate monohydrate) and CC (calcium carbonate).

### Claim 6 (depends on 1)

The process as claimed in claim 1, wherein polymeric adjuvants and/or suspension stabilizers and/or setting retardants and/or radiopaques and/or medicines are added to one or to several of the reactive entities in paste form.

### Claim 7 (depends on 1)

A cement, obtained by the process as claimed in claim 1.

### Claim 8 (depends on 1)

The process as claimed in claim 1, wherein said reactive entities are introduced into a multicompartment device, and a mixing system is used for bringing said reactive entities into contact.

### Claim 9

A method of preparing a calcium phosphate cement for use in surgery or dentistry comprising:
a) providing two reactive entities which are each in paste form,
b) degassing the two reactive entities and then
c) mixing said entities to form the calcium phosphate cement.

### Claim 10

A calcium phosphate cement produced from combining and reacting at least two pasty constituents wherein each constituent of at least two pasty constituents comprise one or more reactive entities and the pasty constituents are degassed prior to combining and reacting.