# US 7,407,494 B2 · Device for delivering medicament

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- Number: US 7,407,494 B2
- Document ID: US7407494B2
- Status: Granted
- Kind: B2
- Application number: 11/045,379
- Filed: 2005-01-31
- Published: 2006-08-10
- Granted: 2008-08-05
- Earliest claimed: 2005-01-31
- Inventors: Anders Boström; Stefan Loof
- Web page: https://patentgrep.com/patent/US7407494B2

## CPC

- A61M 5/31501: {Means for blocking or restricting the movement of the rod or piston (A61M5/5013 takes precedence)}
- A61M 5/2066: {comprising means for injection of two or more media, e.g. by mixing}
- A61M 5/2033: {Spring-loaded one-shot injectors with or without automatic needle insertion (multishot dosing syringes A61M5/31525, needle insertion only A61M5/3287)}
- A61M 5/2448: {comprising means for injection of two or more media, e.g. by mixing}
- A61M 5/3146: {Priming, e.g. purging, reducing backlash or clearance}
- A61M 5/31538: {Permanent blocking, e.g. by medical personnel}
- A61M 2005/2013: {triggering of discharging means by contact of injector with patient body}
- A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)}

## Abstract

A device for delivery of medicament includes a main housing, a container having at least two compartments, each containing a component of the medicament to be injected, and arranged to be connected to a patient delivery element, a longitudinally movable piston and a spring arrangement acting on the piston to exert a force on the components, a first holding element for holding the piston in a force-loaded state, and at least one activator for releasing the piston, a second holding element for stopping the piston when it has moved a certain first distance after one activation of the at least one activator and holding the piston in that position, wherein the force from the piston/spring arrangement and the movement causes the compartments to communicate with each other and the components to mix.

## Claims

### Claim 1

Device for delivery of medicament comprising a main housing, a container including at least two compartments, wherein each compartment contains a component of the medicament to be injected, and arranged to be connected to a patient delivery means, a longitudinally movable piston and a spring arrangement acting on the piston and capable of exerting a force on the components, a first holding means arranged and capable of holding the piston in a force-loaded state, first activator means capable of acting on the first holding means for releasing the piston a certain first distance, wherein the force from the spring arrangement causes the piston to move the first distance, allowing the compartments to communicate with each other and the components to mix, a second holding means capable of stopping the movement of the piston when it has moved the first distance after one activation of the first activator means and holding the piston and the spring arrangement in that position, and dose adjusting means arranged and capable of interacting with the second holding means for adjusting a predetermined dose which corresponds to a second distance to be moved by the piston, wherein a second activator means is capable of acting on the second holding means for further releasing the piston, and wherein, upon a subsequent activation of the first activator means, the force from the spring arrangement causes the piston to move the second distance and eject the predetermined dose through the patient delivery means.

### Claim 2 (depends on 1)

Device according to claim 1, wherein the first and second holding means comprise protrusions arranged on said piston and flexible holding members cooperating with said protrusions.

### Claim 3 (depends on 1)

Device according to claim 1, wherein the first activator means comprises an activator button which upon being depressed, is capable of releasing the first and second holding means.

### Claim 4 (depends on 2)

Device according to claim 2, wherein the dose adjusting means comprises a plurality of protrusions arranged adjacent said piston, where each protrusion is arranged at different axial distance, the piston comprises a ledge capable of cooperating with said plurality of protrusions, and means for aligning a selected one of said plurality of protrusions in the travel path of said piston, thereby defining said second distance.

### Claim 5 (depends on 1)

Device according to claim 1, further comprising a needle shield arranged and capable of extending around the needle upon withdrawal of the injector from the injection site, and capable of locking in that extended position.

### Claim 6

Device for delivery of medicament comprising:
a main housing;
a container including at least two compartments, wherein each compartment contains a component of the medicament to be injected, and arranged to be connected to a patient delivery means;
a longitudinally movable piston and a spring arrangement acting on the piston and capable of exerting a force on said components;
a first holding means arranged and capable of holding the piston in a force-loaded state;
first activator means capable of acting on the first holding means for releasing the piston, wherein the force from the piston/spring arrangement and the movement causes the compartments to communicate with each other and the components to mix;
a second holding means capable of stopping the movement of the piston when it has moved a certain first distance after one activation of the first activator means and holding the piston in that position; and
dose adjusting means arranged and capable of adjusting a second distance of the piston/spring arrangement in order to set a predetermined dose;
wherein a second activator means is capable of acting on the second holding means for releasing the piston; upon a subsequent activation of the first activator means, the piston moves the second distance; the force from the piston/spring arrangement and the movement causes the mixed components to be ejected through the patient delivery means; and
the second holding means comprises threads arranged on said piston, a first and a second nut threaded on said piston, and an abutment wall arranged adjacent said piston, against which the nuts abut when the piston has moved the first distance, means for displacing the second of said nuts in relation to the first nut axially along said piston, wherein said second holding means is capable of holding said first nut, and wherein the second activator means comprises a front end of said device capable of being movable axially upon penetration of said device into a patient, which axial movement causes said second holding means to release said first nut and hold said second nut, where the force of the piston/spring arrangement causes the first nut to rotate and the piston to move.

### Claim 7 (depends on 6)

Device according to claim 6, wherein the means for displacing said second nut constitutes a dose adjusting means and the axial displacement of said second nut corresponds to said second distance.

### Claim 8 (depends on 6)

Device according to claim 6, wherein the dose adjusting means comprises a plurality of protrusions arranged adjacent the piston, where each protrusion is arranged at different axial distance, the piston comprises a ledge capable of cooperating with the plurality of protrusions, and means for aligning a selected one of the plurality of protrusions in the travel path of the piston, thereby defining the second distance.

### Claim 9 (depends on 6)

Device according to claim 6, further comprising a needle shield arranged and capable of extending around the needle upon withdrawal of the injector from the injection site, and capable of locking in that extended position.