# US 7,407,476 B2 · Tissue irradiation with shielding > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 7,407,476 B2 - Document ID: US7407476B2 - Status: Granted - Kind: B2 - Application number: 11/593,952 - Filed: 2006-11-06 - Published: 2007-08-16 - Granted: 2008-08-05 - Earliest claimed: 2005-11-18 - Assignees: SenoRx, Inc. - Inventors: Paul Lubock; Michael L. Jones - Web page: https://patentgrep.com/patent/US7407476B2 ## CPC - A61N 5/1015: {Treatment of resected cavities created by surgery, e.g. lumpectomy} - A61B 2017/3419: {Sealing means between cannula and body} - A61N 2005/1005: {with asymmetrical radiation pattern} - A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B) - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) ## Abstract Devices and methods are disclosed for treatment to tissue surrounding a body cavity or other intracorporeal site, such as after removal of tissue, e.g. cancer. Such a device includes a treatment location on a distal portion of the device with one or more radiation shielding components that partially encircle a radiation source at the treatment location to control emitted radiation from the radiation source. The device minimizes radiation damage to healthy tissue surrounding the body cavity or other site while irradiating tissue not shielded by the radiation shielding components. A device embodying features of the invention can include a sealing member at a location on a shaft of the device proximal to a treatment location to seal the passageway leading to the body cavity. ## Claims ### Claim 1 A device for treating a body cavity or other intracorporeal site within a patient, comprising: a.) an elongated shaft having a longitudinal axis, a distal portion with a treatment location and an arcuate shaped lumen which is off set from the longitudinal axis and which extends within the shaft to the treatment location: b.) a radiation source configured to be disposed or is disposed in the treatment location; and c.) an arcuate shaped radiation shielding component which is slidably disposed within the arcuate shaped lumen and which partially encircles or is configured to partially encircle the treatment location to shield tissue surrounding in part the cavity or other intracorporeal site from radiation emitted from the radiation source and to facilitate irradiation of tissue surrounding the cavity or other intracorporeal site not shielded by the radiation shielding component. ### Claim 2 (depends on 1) The device of claim 1 wherein part of the radiation shielding component is configured to be deployed proximal to the treatment location. ### Claim 3 (depends on 1) The device of claim 1 wherein part of the radiation shielding component is configured to be deployed distal to the treatment location. ### Claim 4 (depends on 1) The device of claim 1 wherein the radiation shield defines in part a window which allows radiation to impinge tissue at the body cavity or other intracorporeal site for treatment. ### Claim 5 (depends on 4) The device of claim 4 wherein the length of the window is about 2 millimeters to about 5 centimeters. ### Claim 6 (depends on 5) The device of claim 5 wherein the radiation shield has an arcuate shielded area with an angular range between about 20° to about 240°. ### Claim 7 (depends on 1) The device of claim 1 wherein the radiation shielding component slidably disposed within the elongate shaft has a distal radiation shield configured to be deployed distal to the treatment location and a proximal radiation shield configured to be deployed proximal to the treatment location. ### Claim 8 (depends on 7) The device of claim 7 wherein spacing between the proximal and distal radiation shields is adjustable. ### Claim 9 (depends on 8) The device of claim 8 wherein spacing between the proximal and distal radiation shields is partially shielded by the central radiation shield which partially encircles the treatment location and extends between the proximal and distal radiation shields. ### Claim 10 (depends on 1) The device of claim 1 wherein the elongated shaft is partitioned to provide a plurality of lumens divided by spacing elements that are configured to receive shielding shields. ### Claim 11 (depends on 1) The device of claim 1 including an elongated shaft which has an inner lumen leading to the treatment location configured to deliver the radiation source to the treatment location. ### Claim 12 (depends on 11) The device of claim 11 wherein the radiation source is a solid material. ### Claim 13 (depends on 12) The device of claim 12 wherein the radiation source is a brachytherapy seed. ### Claim 14 (depends on 11) The device of claim 11 wherein the radiation source is selected from the group consisting of a liquid containing a radioactive iodine isotope, a slurry containing a solid radioactive isotope, a gel containing a solid radioactive isotope, or a microminiature x-ray tube. ### Claim 15 (depends on 1) The device of claim 1 including a cavity filling member which at least in part fills the body cavity or other intracorporeal site and which surrounds at least in part the treatment location. ### Claim 16 (depends on 15) The device of claim 15 wherein the cavity filling member is expandable. ### Claim 17 (depends on 16) The device of claim 16 wherein the cavity filling member is inflatable. ### Claim 18 (depends on 17) The device of claim 17 wherein the cavity filling member has an interior configured to receive inflation fluid. ### Claim 19 (depends on 18) The device of claim 18 wherein the cavity filling member is a balloon. ### Claim 20 (depends on 19) The device of claim 19 including an inflation lumen which is in fluid communication with an interior of the balloon. ### Claim 21 (depends on 15) The device of claim 15 wherein the radiation shielding component is part of the cavity filling member. ### Claim 22 (depends on 21) The device of claim 21 wherein the radiation shielding portion of the cavity filling member has an oval shape. ### Claim 23 (depends on 22) The device of claim 22 wherein the oval shaped radiation shielding portion of the cavity filling member is longitudinally oriented. ### Claim 24 (depends on 21) The device of claim 21 wherein the radiation shielding portion of the cavity filling member has a circular shape. ### Claim 25 (depends on 21) The device of claim 21 wherein the radiation shielding portion of the cavity filling member has the shape of a spherical segment and is located at an end of the cavity filling member. ### Claim 26 (depends on 15) The device of claim 15 wherein the cavity filling member is spherical shaped. ### Claim 27 (depends on 15) The device of claim 15 wherein the cavity filling member is oval shaped. ### Claim 28 (depends on 1) The device of claim 1 wherein the radiation shielding component is formed at least in part of radiation absorbing material. ### Claim 29 (depends on 28) The device of claim 28 wherein the radiation absorbing material is selected from a group consisting of tantalum, bismuth subcarbonate, barium sulfate, platinum, gold, and tungsten. ### Claim 30 (depends on 1) The device of claim 1 wherein a portion of the radiation shielding component contains a lesser amount of the radiation absorbing material than other portions of the radiation shielding component. ### Claim 31 (depends on 1) The device of claim 1 including an elongated shaft which has a vacuum lumen configured to be in fluid communication with a vacuum source and one or more vacuum ports in the exterior of the elongated shaft to provide a vacuum within the body cavity or other intracorporeal site. ### Claim 32 A system for treating a body cavity or other intracorporeal site within a patient, comprising: a.) an elongate shaft having a proximal end, a distal end, and a treatment location in a distal portion of the elongate shaft, first and second lumens extending within the shaft to the treatment location; b.) a source for a treatment agent configured to be disposed in the treatment location; and c.) a cavity filling member on the elongated shaft surrounding the treatment location having an interior which is in fluid communication with the first lumen; d.) a source for inflation fluid which is in fluid communication with the first lumen; a.) an bladder within the cavity filling member defining at least in part an separate chamber within the interior of the cavity filling member which is in fluid communication with and receives contrast material from the second lumen and which is at least in part spaced away from the elongated shaft. ### Claim 33 (depends on 32) The system of claim 32 wherein the treatment agent is a radiation source. ### Claim 34 (depends on 33) The system of claim 33 wherein the radiation source is a brachytherapy seed. ### Claim 35 (depends on 33) The system of claim 33 wherein the radiation source is selected from the group consisting of a liquid containing a radioactive iodine isotope, a slurry containing solid radioactive isotope, a gel containing a solid radioactive isotope, or a microminiature x-ray tube. ### Claim 36 (depends on 32) The system of claim 32 wherein the device has an third lumen configured to deliver the treatment agent to the treatment location at the distal portion of the shaft. ### Claim 37 (depends on 33) The system of claim 33 wherein the cavity filling member is configured to at least partially fill the body cavity.