Methods and systems for correcting image misalignment
OwnerThomas Clune, Philippe Schmid +1inventors
InventorsThomas Clune, Philippe Schmid, Chunsheng Jiang
Life of this patent
Estimating the term…
Abstract
The invention provides methods of determining a correction for a misalignment between at least two images in a sequence of images due at least in part to sample movement. The methods are applied, for example, in the processing and analysis of a sequence of images of biological tissue in a diagnostic procedure. The invention also provides methods of validating the correction for a misalignment between at least two images in a sequence of images of a sample. The methods may be applied in deciding whether a correction for misalignment accurately accounts for sample motion.
Claims14
A method of validating a correction for an image misalignment, the method comprising the steps of:
- adjusting at least one of two or more images using a correction for an image misalignment between the two or more images;
- defining one or more validation cells, each of which includes a common area of the two or more adjusted images;
- computing for each of the one or more validation cells a measure of displacement between the two or more adjusted images using data from the two or more adjusted images corresponding to each of the one or more validation cells;
- and
- validating the correction for the image misalignment by comparing at least one of the measures of displacement with a threshold value.
A method of validating a correction for an image misalignment, the method comprising the steps of:
- defining one or more validation cells within a bounded image plane;
- computing for each of the one or more validation cells a measure of displacement between two or more images bound by the image plane using data from the two or more images corresponding to each of the one or more validation cells;
- validating a correction for an image misalignment between the two or more images by comparing at least one of the measures of displacement with the correction.
A method of validating a correction for an image misalignment, the method comprising the steps of:
- obtaining a plurality of sequential images of a sample using an optical signal detection device;
- determining a correction for a misalignment between at least two of the sequential images, the misalignment due at least in part to a movement of the sample;
- and
- validating the correction between at least a first image and a second image of the plurality of sequential images;
- wherein the determination of a correction for a misalignment between a first and a second image and the validation of said correction are performed in less than about one second.
Dependencies are inferred from the claim text.