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US 7,405,821 B2Granted
Method of instrument standardization for a spectroscopic device
AssigneePerkinElmer LAS, Inc.
InventorsYongdong Wang, Bernhard H. Radziuk, David H. Tracy
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AssigneePerkinElmer LAS, Inc.
InventorsYongdong Wang, Bernhard H. Radziuk, David H. Tracy
Estimating the term…
In a spectroscopic process a sample for producing a test spectral line or spectrum of at least one component contained in the sample is stimulated and the transmitted and/or emitted electromagnetic rays are used to create the test spectral line or spectrum. In order to improve such a spectroscopic process to such an extent that variations of certain parameters, which alter the shape and/or occurrence of a spectral line, are compensated, a comparison spectral line or spectrum of a known comparison material is produced under substantially the same parameters as the sample. The comparison spectral line or spectrum is compared with an ideal comparison spectral line or spectrum in order to calculate a transfer function, and the transfer function is applied to the test spectral line or spectrum in order to calculate a corrected test spectral line or spectrum.
A method of standardization for a spectroscopic device comprising the steps of:
A spectroscopic process whereby, in a spectroscopic device having a detector, at least one component contained in a sample is stimulated and a first signal indicative of a test spectral line or spectrum of the at least one component in the sample is produced using the detector, characterized in that, a comparison material is stimulated, simultaneously with the at least one component in the sample, and a second signal indicative of a comparison spectral line or spectrum is produced using the detector, a transfer function is obtained for the known comparison material by using the second signal indicative of the comparison spectral line or spectrum produced using the detector, which transfer function translates the comparison spectral line or spectrum into a corrected ideal comparison spectral line or spectrum, the transfer function derived from the comparison spectral line or spectrum and the ideal comparison spectral line or spectrum, and the transfer function is applied to the test spectral line or spectrum, wherein the ideal comparison spectral line or spectrum is generated based on prescribed values of parameters selected from the group consisting of:
Dependencies are inferred from the claim text.