Process for the preparation of carbamates
AssigneeCouncil of Scientific and Industrial Research
InventorsDarbha Srinivas, Rajendra Srivastava, Paul Ratnasamy
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Abstract
The present invention provides an improved process for the preparation of carbamates with high selectivity of pharmaceutical interest by an eco-friendly, non-toxic, phosgene-/isocyanate-/CO-free clean route through a reaction of amine, organic halide compound and carbon dioxide in the presence of a solid, reusable catalyst at moderate conditions and does not require additional cocatalyst/promoter as well as solvent.
Claims7
An improved process for the preparation of carbamates, which comprises reacting amine and alkyl halide in presence of an ordered, bi-functional mesoporous silica catalyst with a molar composition of:
- X Mo2. (1−x) SiO2.y B
- wherein B is adenine, M is Ti4+ ions, x lies between 0.0095 and 0.025 moles;
- y varies between 0.054 and 0.12 moles, and
- wherein said reacting is in an autoclave, under CO2 pressure of about 3.4 bar, at a temperature of about 80° C., for a period of about 4 hours cooling the above said reaction mixture to a temperature of about 25° C. and removing the unreacted CO2, followed by the separation of the catalyst by filtration to obtain the desired product.
Dependencies are inferred from the claim text.