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US 7,405,298 B2Granted
Process for making risperidone and intermediates therefor
AssigneeSynthon IP Inc.
InventorsPavel Slanina, Jiri Bartl
Life of this patent
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Abstract
The formation of risperidone is enhanced by the use of enriched Z-isomer oxime intermediate(s) of formula (3) or (7). The oxime(s) can be isomerically enriched by a variety of techniques including the use of the novel acetic acid salt thereof, which affords, inter alia, resolution of the isomers and/or by heat conversion.
Claims10
An acetic acid salt of a compound of formula (3) or (7):
- wherein said salt of formula (3) contains more of the Z-isomer of formula (3) than of the E-isomer of formula (3).
An enriched Z-isomer oxime of formula (3) or (7):
- wherein the amount of Z-isomer is at least 95%, based on the total amount of said oxime.
Dependencies are inferred from the claim text.