Certain imidazo[1,2-a]pyrazin-8-ylamines and method of inhibition of Bruton's tyrosine kinase by such compounds

The compound having a structure of Formula 6

• or a pharmaceutically acceptable salt, hydrate, or diastereomer thereof, wherein
• A is chosen from 0 and 1;
• R1 is chosen from
• phenyl,
• phenyl substituted with a group chosen from
• —CHO,
• —COOH,
• —CONH2,
• —CONHOH,
• C2-C6 alkenyl,
• substituted C2-C6 alkenyl chosen from mono-, di-, and tri-substituted C2-C6 alkenyl wherein the substituents are independently selected from halogen, hydroxy, amino, oxo, —COOH, —CONH2, C1-C4alkyl, C2-C4alkenyl, C2-C4alkynyl, C1-C4alkoxy, C2-C4alkanoyl, C1-C4alkylthio, C1-C2haloalkyl, C1-C2haloalkoxy, C1-C4alkoxycarbonyl, mono-C1-C4alkylamino, di-C1-C4alkylamino, mono-C1-C4alkylcarboxamide, di-C1-C4alkylcarboxamide, and phenyl,
• C2-C6 alkynyl,
• substituted C2-C6 alkynyl chosen from mono-, di-, and tri-substituted C2-C6 alkynyl wherein the substituents are independently selected from halogen, hydroxy, amino, oxo, —COOH, —CONH2, C1-C4alkyl, C2-C4alkenyl, C2-C4alkynyl, C1-C4alkoxy, C2-C4alkanoyl, C1-C4alkylthio, C1-C2haloalkyl, C1-C2haloalkoxy, C1-C4alkoxycarbonyl, mono-C1-C4alkylamino, di-C1-C4alkylamino, mono-C1-C4alkylcarboxamide, di-C1-C4alkylcarboxamide, and phenyl,
• C1-C6hydroxyalkyl,
• substituted C1-C6hydroxyalkyl chosen from mono-, di-, and tri-substituted C1-C6hydroxyalkyl wherein the substituents are independently selected from halogen, hydroxy, amino, oxo, —COOH, —CONH2, C1-C4alkyl, C2-C4alkenyl, C2-C4alkynyl, C1-C4alkoxy, C2-C4alkanoyl, C1-C4alkylthio, C1-C2haloalkyl, C1-C2haloalkoxy, C1-C4alkoxycarbonyl, mono-C1-C4alkylamino, di-C1-C4alkylamino, mono-C1-C4alkylcarboxamide, di-C1-C4alkylcarboxamide, and phenyl,
• C1-C6hydroxyalkoxy,
• substituted C1-C6hydroxyalkoxy chosen from mono-, di-, and tri-substituted C1-C6hydroxyalkoxy wherein the substituents are independently selected from halogen, hydroxy, amino, oxo, —COOH, —CONH2, C1-C4alkyl, C2-C4alkenyl, C2-C4alkynyl, C1-C4alkoxy, C2-C4alkanoyl, C1-C4alkylthio, C1-C2haloalkyl, C1-C2haloalkoxy, C1-C4alkoxycarbonyl, mono-C1-C4alkylamino, di-C1-C4alkylamino, mono-C1-C4alkylcarboxamide, di-C1-C4alkylcarboxamide, and phenyl,
• (mono-C1-C6alkylamino)C1-C6alkoxy,
• substituted (mono-C1-C6alkylamino)C1-C6alkoxy chosen from mono-, di-, and tri-substituted (mono-C1-C6alkylamino)C1-C6alkoxy wherein the substituents are independently selected from halogen, hydroxy, amino, oxo, —COOH, —CONH2, C1-C4alkyl, C2-C4alkenyl, C2-C4alkynyl, C1-C4alkoxy, C2-C4alkanoyl, C1-C4alkylthio, C1-C2haloalkyl, C1-C2haloalkoxy, C1-C4alkoxycarbonyl, mono-C1-C4alkylamino, di-C1-C4alkylamino, mono-C1-C4alkylcarboxamide, di-C1-C4alkylcarboxamide, and phenyl,
• (di-C1-C6alkylamino)C1-C6alkoxy,
• substituted (di-C1-C6alkylamino)C1-C6alkoxy chosen from mono-, di-, and tri-substituted (di-C1-C6alkylamino)C1-C6alkoxy wherein the substituents are independently selected from halogen, hydroxy, amino, oxo, —COOH, —CONH2, C1-C4alkyl, C2-C4alkenyl, C2-C4alkynyl, C1-C4alkoxy, C2-C4alkanoyl, C1-C4alkylthio, C1-C2haloalkyl, C1-C4haloalkoxy, C1-C4alkoxycarbonyl, mono-C1-C4alkylamino, di-C1-C4alkylamino, mono-C1-C4alkylcarboxamide, di-C1-C4alkylcarboxamide, and phenyl,
• (C1-C6alkoxy)(C1-C6alkylamino)C0-C6alkyl,
• substituted (C1-C6alkoxy)(C1-C6alkylamino)C0-C6alkyl chosen from mono-, di- and tri-substituted (C1-C6alkoxy)(C1-C6alkylamino) C0-C6alkyl, wherein the substituents are independently selected from halogen, hydroxy, amino, oxo, —COOH, —CONH2, C1-C4alkyl, C2-C4alkenyl, C2-C4alkynyl, C1-C4alkoxy, C2-C4alkanoyl, C1-C4alkylthio, C1-C2haloalkyl, C1-C2haloalkoxy, C1-C4alkoxycarbonyl, mono-C1-C4alkylamino, di-C1-C4alkylamino, mono-C1-C4alkylcarboxamide, di-C1-C4alkylcarboxamide, and phenyl,
• (C1-C6alkoxy)(C1-C6alkoxy)C1-C6alkoxy,
• substituted (C1-C6alkoxy)(C1-C6alkoxy) C1-C6alkoxy chosen from mono-, di-, and tri-substituted (C1-C6alkoxy)(C1-C6alkoxy)C1-C6alkoxy wherein the substituents are independently selected from halogen, hydroxy, amino, oxo, —COOH, —CONH2, C1-C4alkyl, C2-C4alkenyl, C2-C4alkynyl, C1-C4alkoxy, C2-C4alkanoyl, C1-C4alkylthio, C1-C2haloalkyl, C1-C2haloalkoxy, C1-C4alkoxycarbonyl, mono-C1-C4alkylamino, di-C1-C4alkylamino, mono-C1-C4alkylcarboxamide, di-C1-C4alkylcarboxamide, and phenyl,
• heterocycloalkyl,
• substituted heterocycloalkyl chosen from mono-, di-, and tri-substituted heterocycloalkyl wherein the substituents are independently selected from halogen, hydroxy, amino, oxo, —COOH, —CONH2, C1-C4alkyl, C2-C4alkenyl, C2-C4alkynyl, C1-C4alkoxy, C2-C4alkanoyl, C1-C4alkylthio, C1-C2haloalkyl, C1-C2haloalkoxy, C1-C4alkoxycarbonyl, mono-C1-C4alkylamino, di-C1-C4alkylamino, mono-C1-C4alkylcarboxamide, di-C1-C4alkylcarboxamide, and phenyl,
• aryl,
• substituted aryl chosen from mono-, di-, and tri-substituted aryl wherein the substituents are independently selected from halogen, hydroxy, amino, oxo, —COOH, —CONH2, C1-C4alkyl, C2-C4alkenyl, C2-C4alkynyl, C1-C4alkoxy, C2-C4alkanoyl, C1-C4alkylthio, C1-C2haloalkyl, C1-C2haloalkoxy, C1-C4alkoxycarbonyl, mono-C1-C4alkylamino, di-C1-C4alkylamino, mono-C1-C4alkylcarboxamide, di-C1-C4alkylcarboxamide, and phenyl,
• heteroaryl,
• substituted heteroaryl chosen from mono-, di-, and tri-substituted heteroaryl wherein the substituents are independently selected from halogen, hydroxy, amino, oxo, —COOH, —CONH2, C1-C4alkyl, C2-C4alkenyl, C2-C4alkynyl, C1-C4alkoxy, C2-C4alkanoyl, C1-C4alkylthio, C1-C2haloalkyl, C1-C2haloalkoxy, C1-C4alkoxycarbonyl, mono-C1-C4alkylamino, di-C1-C4alkylamino, mono-C1-C4alkylcarboxamide, di-C1-C4alkylcarboxamide, and phenyl,
• —C1-C6alkyl(C═O)OR10,
• substituted —C1-C6alkyl(C═O)OR10 chosen from mono-, di-, and tri-substituted —C1-C6alkyl(C═O)OR10 wherein the substituents are independently selected from halogen, hydroxy, amino, oxo, —COOH, —CONH2, C1-C4alkyl, C2-C4alkenyl, C2-C4alkynyl, C1-C4alkoxy, C2-C4alkanoyl, C1-C4alkylthio, C1-C2haloalkyl, C1-C2haloalkoxy, C1-C4alkoxycarbonyl, mono-C1-C4alkylamino, di-C1-C4alkylamino, mono-C1-C4alkylcarboxamide, di-C1-C4alkylcarboxamide, and phenyl,
• —C0-C6alkyl(C═O)NR10R11,
• substituted —C0-C6alkyl(C═O)NR10R11 chosen from mono-, di-, and tri-substituted C0-C6alkyl(C═O)NR10R11 wherein the substituents are independently selected from halogen, hydroxy, amino, oxo, —COOH, —CONH2, C1-C4alkyl, C2-C4alkenyl, C2-C4alkynyl, C1-C4alkoxy, C2-C4alkanoyl, C1-C4alkylthio, C1-C2haloalkyl, C1-C2haloalkoxy, C1-C4alkoxycarbonyl, mono-C1-C4alkylamino, di-C1-C4alkylamino, mono-C1-C4alkylcarboxamide, di-C1-C4alkylcarboxamide, and phenyl,
• —C1-C6alkylNR10(SO2)R11,
• substituted —C1-C6alkylNR10(SO2)R11 chosen from mono-, di-, and tri-substituted —C1-C6alkylNR10(SO2)R11 wherein the substituents are independently selected from halogen, hydroxy, amino, oxo, —COOH, —CONH2, C1-C4alkyl, C2-C4alkenyl, C2-C4alkynyl, C1-C4alkoxy, C2-C4alkanoyl, C1-C4alkylthio, C1-C2haloalkyl, C1-C2haloalkoxy, C1-C4alkoxycarbonyl, mono-C1-C4alkylamino, di-C1-C4alkylamino, mono-C1-C4alkylcarboxamide, di-C1-C4alkylcarboxamide, and phenyl,
• —C0-C6alkylNR10(C═O)R11,
• substituted —C0-C6alkylNR10(C═O)R11 chosen from mono-, di-, and tri-substituted —C0-C6alkylNR10(C═O)R11, wherein the substituents are independently selected from halogen, hydroxy, amino, oxo, —COOH, —CONH2, C1-C4alkyl, C2-C4alkenyl, C2-C4alkynyl, C1-C4alkoxy, C2-C4alkanoyl, C1-C4alkylthio, C1-C2haloalkyl, C1-C2haloalkoxy, C1-C4alkoxycarbonyl, mono-C1-C4alkylamino, di-C1-C4alkylamino, mono-C1-C4alkylcarboxamide, di-C1-C4alkylcarboxamide, and phenyl,
• —C0-C6alkyl(SO2)R10,
• substituted —C0-C6alkyl(SO2)R10 chosen from mono-, di-, and tri-substituted —C0-C6alkyl(SO2)R10 wherein the substituents are independently selected from halogen, hydroxy, amino, oxo, —COOH, —CONH2, C1-C4alkyl, C2-C4alkenyl, C2-C4alkynyl, C1-C4alkoxy, C2-C4alkanoyl, C1-C4alkylthio, C1-C2haloalkyl, C1-C2haloalkoxy, C1-C4alkoxycarbonyl, mono-C1-C4alkylamino, di-C1-C4alkylamino, mono-C1-C4alkylcarboxamide, di-C1-C4alkylcarboxamide, and phenyl,
• —C0-C6alkylNR10(C═O)NR11R12
• substituted —C0-C6alkylNR10(C═O)NR11R12 chosen from mono-, di-, and tri-substituted —C0-C6alkyl(C═O)NR11R12, wherein the substituents are independently selected from halogen, hydroxy, amino, oxo, —COOH, —CONH C1-C4alkyl, C2-C4alkenyl, C2-C4alkynyl, C1-C4alkoxy, C2-C4alkanoyl, C1-C4alkylthio, C1-C2haloalkyl, C1-C2haloalkoxy, C1-C4alkoxycarbonyl, mono-C1-C4alkylamino, di-C1-C4alkylamino, mono-C1-C4alkylcarboxamide, di-C1-C4alkylcarboxamide, and phenyl, and
• -L-G, where
• L is chosen from
• C1-C2alkylene,
• substituted C1-C2alkylene chosen from mono-, di-, and tri-substituted C1-C2alkylene wherein the substituents are independently selected from halogen, hydroxy, amino, oxo, —COOH, —CONH2, C1-C4alkyl, C2-C4alkenyl, C2-C4alkynyl, C1-C4alkoxy, C2-C4alkanoyl, C1-C4alkylthio, C1-C2haloalkyl, C1-C2haloalkoxy, C1-C4alkoxycarbonyl, mono-C1-C4alkylamino, di-C1-C4alkylamino, mono-C1-C4alkylcarboxamide, di-C1-C4alkylcarboxamide, and phenyl,
• C0-C2alkylene-O—,
• substituted C0-C2alkylene-O— chosen from mono-, di-, and tri-substituted C0-C2alkylene-O— wherein the substituents are independently selected from halogen, hydroxy, amino, oxo, —COOH, —CONH2, C1-C4alkyl, C2-C4alkenyl, C2-C4alkynyl, C1-C4alkoxy, C2-C4alkanoyl, C1-C4alkylthio, C1-C2haloalkyl, C1-C2haloalkoxy, C1-C4alkoxycarbonyl, mono-C1-C4alkylamino, di-C1-C4alkylamino, mono-C1-C4alkylcarboxamide, di-C1-C4alkylcarboxamide, and phenyl,
• —(C═O)—,
• —(C1-C2alkylene)(C═O)—, and
• substituted —(C1-C2alkylene)(C═O)— chosen from mono-, di-, and tri-substituted —(C1-C2alkylene)(C═O)— wherein the substituents are independently selected from halogen, hydroxy, amino, oxo, —COOH, —CONH2, C1-C4alkyl, C2-C4alkenyl, C2-C4alkynyl, C1-C4alkoxy, C1-C4alkanoyl, C1-C4alkylthio, C1-C2haloalkyl, C1-C2haloalkoxy, C1-C4alkoxycarbonyl, mono-C1-C4alkylamino, di-C1-C4alkylamino, mono-C1-C4alkylcarboxamide, di-C1-C4alkylcarboxamide, and phenyl, and
• G is chosen from
• heterocycloalkyl,
• substituted heterocycloalkyl chosen from mono-, di-, and tri-substituted heterocycloalkyl, wherein the substituents are independently selected from halogen, hydroxy, amino, oxo, —COOH, —CONH2, C1-C4alkyl, C2-C4alkenyl, C2-C4alkynyl, C1-C4alkoxy, C2-C4alkanoyl, C1-C4alkylthio, C1-C2haloalkyl, C1-C2haloalkoxy, C1-C4alkoxycarbonyl, mono-C1-C4alkylamino, di-C1-C4alkylamino, mono-C1-C4alkylcarboxamide, di-C1-C4alkylcarboxamide, and phenyl,
• C3-C7cycloalkyl,
• substituted C3-C7cycloalkyl chosen from mono-, di-, and tri-substituted C3-C7cycloalkyl wherein the substituents are independently selected from halogen hydroxy, amino, oxo, —COOH, —CONH2, C1-C4alkyl, C2-C4alkenyl, C2-C4alkynyl, C1-C4alkoxy, C2-C4alkanoyl, C1-C4alkylthio, C1-C2haloalkyl, C1-C2haloalkoxy, C1-C4alkoxycarbonyl, mono-C1-C4alkylamino, di-C1-C4alkylamino, mono-C1-C4alkylcarboxamide, di-C1-C4alkylcarboxamide, and phenyl,
• aryl,
• substituted aryl chosen from mono-, di-, and tri-substituted aryl wherein the substituents are independently selected from halogen, hydroxy, amino, oxo, —COOH, —CONH2, C1-C4alkyl, C2-C4alkenyl, C2-C4alkynyl, C1-C4alkoxy, C2-C4alkanoyl, C1-C4alkylthio, C1-C2haloalkyl, C1-C2haloalkoxy, C1-C4alkoxycarbonyl, mono-C1-C4alkylamino, di-C1-C4alkylamino, mono-C1-C4alkylcarboxamide, di-C1-C4alkylcarboxamide, and phenyl,
• heteroaryl, and
• substituted heteroaryl chosen from mono-, di-, and tri-substituted heteroaryl wherein the substituents are independently selected from halogen, hydroxy, amino, oxo, —COOH, —CONH2, C1-C4alkyl, C2-C4alkenyl, C2-C4alkynyl, C1-C4alkoxy, C2-C4alkanoyl, C1-C4alkylthio, C1-C2haloalkyl, C1-C2haloalkoxy, C1-C4alkoxycarbonyl, mono-C1-C4alkylamino, di-C1-C4alkylamino, mono-C1-C4alkylcarboxamide, di-C1-C4alkylcarboxamide, and phenyl, and
• monocyclic heteroaryl,
• monocyclic heteroaryl substituted with a group chosen from
• hydroxy,
• —CHO,
• —COOH,
• —CONH2,
• —CONHOH,
• C2-C6 alkenyl,
• substituted C2-C6 alkenyl chosen from mono-, di-, and tri-substituted C2-C6 alkenyl wherein the substituents are independently selected from halogen, hydroxy, amino, oxo, —COOH, —CONH2, C1-C4 alkyl, C2-C4 alkenyl, C2-C4alkynyl, C1-C4alkoxy, C2-C4alkanoyl, C1-C4alkylthio, C1-C2haloalkyl, C1-C2haloalkoxy, C1-C4alkoxycarbonyl, mono-C1-C4alkylamino, di-C1-C4alkylamino, mono-C1-C4alkylcarboxamide, di-C1-C4alkylcarboxamide, and phenyl,
• C2-C6 alkynyl,
• substituted C2-C6alkynyl chosen from mono-, di-, and tri-substituted C2-C6 alkynyl wherein the substituents are independently selected from halogen, hydroxy, amino, oxo, —COOH, —CONH2, C1-C4alkyl, C2-C4alkenyl, C2-C4alkynyl, C1-C4alkoxy, C2-C4alkanoyl, C1-C4alkylthio, C1-C2haloalkyl, C1-C2haloalkoxy, C1-C4alkoxycarbonyl, mono-C1-C4alkylamino, di-C1-C4alkylamino, mono-C1-C4alkylcarboxamide, di-C1-C4alkylcarboxamide, and phenyl,
• C1-C6hydroxyalkyl,
• substituted C1-C6hydroxyalkyl chosen from mono-, di-, and tri-substituted C1-C6hydroxyalkyl wherein the substituents are independently selected from halogen, hydroxy, amino, oxo, —COOH, —CONH2, C1-C4alkyl, C2-C4alkenyl, C2-C4alkynyl, C1-C4alkoxy, C2-C4alkanoyl, C1-C4alkylthio, C1-C2haloalkyl, C1-C2haloalkoxy, C1-C4alkoxycarbonyl, mono-C1-C4alkylamino, di-C1-C4alkylamino, mono-C1-C4alkylcarboxamide, di-C1-C4alkylcarboxamide, and phenyl,
• C1-C6hydroxyalkoxy,
• substituted C1-C6hydroxyalkoxy chosen from mono-, di-, and tri-substituted C1-C6hydroxyalkoxy wherein the substituents are independently selected from halogen, hydroxy, amino, oxo, —COOH, —CONH2, C1-C4alkyl, C2-C4alkenyl, C2-C4alkynyl, C1-C4alkoxy, C2-C4alkanoyl, C1-C4alkylthio, C1-C2haloalkyl, C1-C4haloalkoxy, C1-C4alkoxycarbonyl, mono-C1-C4alkylamino, di-C1-C4alkylamino, mono-C1-C4alkylcarboxamide, di-C1-C4alkylcarboxamide, and phenyl,
• (mono-C1-C6alkylamino)C1-C6alkoxy,
• substituted (mono-C1-C6alkylamino)C1-C6alkoxy chosen from mono-, di-, and tri-substituted (mono-C1-C6alkylamino)C1-C6alkoxy wherein the substituents are independently selected from halogen, hydroxy, amino, oxo, —COOH, —CONH2, C1-C4alkyl, C2-C4alkenyl, C2-C4alkynyl, C2-C4alkanoyl, C1-C4alkylthio, C1-C2haloalkyl, C1-C2haloalkoxy, C1-C4alkoxycarbonyl, mono-C1-C4alkylamino, di-C1-C4alkylamino, mono-C1-C4alkylcarboxamide, di-C1-C4alkylcarboxamide, and phenyl,
• (di-C1-C6alkylamino)C1-C6alkoxy,
• substituted (di-C1-C6alkylamino)C1-C6alkoxy chosen from mono-, di-, and tri-substituted (di-C1-C6alkylamino)C1-C6alkoxy wherein the substituents are independently selected from halogen, hydroxy, amino, oxo, —COOH, —CONH2, C1-C4alkyl, C2-C4alkenyl, C2-C4alkynyl, C1-C4alkoxy, C2-C4alkanoyl, C1-C4alkylthio, C1-C2haloalkyl, C1-C2haloalkoxy, C1-C4alkoxycarbonyl, mono-C1-C4alkylamino, di-C1-C4alkylamino, mono-C1-C4alkylcarboxamide, di-C1-C4alkylcarboxamide, and phenyl,
• (C1-C6alkoxy)(C1-C6alkylamino)C0-C6alkyl
• substituted (C1-C6alkoxy)(C1-C6alkylamino)C0-C6alkyl chosen from mono-, di-, and tri-substituted (C1-C6alkoxy)(C1-C6alkylamino)C0-C6alkyl, wherein the substituents are independently selected from halogen, hydroxy, amino, oxo, —COOH, —CONH2, C1-C4alkyl, C2-C4alkenyl, C2-C4alkynyl, C1-C4alkoxy, C2-C4alkanoyl, C1-C4alkylthio, C1-C2haloalkyl, C1-C2haloalkoxy, C1-C4alkoxycarbonyl, mono-C1-C4alkylamino, di-C1-C4alkylamino, mono-C1-C4alkylcarboxamide, di-C1-C4alkylcarboxamide, and phenyl,
• (C1-C6alkoxy)(C1-C6alkoxy)C1-C6alkoxy,
• substituted (C1-C6alkoxy)(C1-C6alkoxy)C1-C6alkoxy chosen from mono-, di-, and tri-substituted (C1-C6alkoxy)(C1-C6alkoxy)C1-C6alkoxy wherein the substituents are independently selected from halogen, hydroxy, amino, oxo, —COOH, —CONH2, C1-C4alkyl, C2-C4alkenyl, C2-C4alkynyl, C1-C4alkoxy, C2-C4alkanoyl, C1-C4alkylthio, C1-C2haloalkyl, C1-C2haloalkoxy, C1-C4alkoxycarbonyl, mono-C1-C4alkylamino, di-C1-C4alkylamino, mono-C1-C4alkylcarboxamide, di-C1-C4alkylcarboxamide, and phenyl,
• heterocycloalkyl,
• substituted heterocycloalkyl chosen from mono-, di-, and tri-substituted heterocycloalkyl wherein the substituents are independently selected from halogen, hydroxy, amino, oxo, —COOH, —CONH2, C1-C4alkyl, C2-C4alkenyl, C2-C4alkynyl, C1-C4alkoxy, C2-C4alkanoyl, C1-C4alkylthio, C1-C2haloalkyl, C1-C2haloalkoxy, C1-C4alkoxycarbonyl, mono-C1-C4alkylamino, di-C1-C4alkylamino, mono-C1-C4alkylcarboxamide, di-C1-C4alkylcarboxamide, and phenyl,
• aryl,
• substituted aryl chosen from mono-, di-, and tri-substituted aryl wherein the substituents are independently selected from halogen, hydroxy, amino, oxo, —COOH, —CONH2, C1-C4alkyl, C2-C4alkenyl, C2-C4alkynyl, C1-C4alkoxy, C2-C4alkanoyl, C1-C4alkylthio, C1-C2haloalkyl, C1-C2haloalkoxy, C1-C4alkoxycarbonyl, mono-C1-C4alkylamino, di-C1-C4alkylamino, mono-C1-C4alkylcarboxamide, di-C1-C4alkylcarboxamide, and phenyl,
• heteroaryl
• substituted heteroaryl chosen from mono-, di-, and tri-substituted heteroaryl wherein the substituents are independently selected from halogen, hydroxy, amino, oxo, —COOH, —CONH2, C1-C4alkyl, C2-C4alkenyl, C2-C4alkynyl, C1-C4alkoxy, C2-C4alkanoyl, C1-C4alkylthio, C1-C2haloalkyl, C1-C2haloalkoxy, C1-C4alkoxycarbonyl, mono-C1-C4alkylamino, di-C1-C4alkylamino, mono-C1-C4alkylcarboxamide, di-C1-C4alkylcarboxamide, and phenyl,
• —C1-C6alkyl(C═O)OR10,
• substituted —C1-C6alkyl(C═O)OR10 chosen from mono-, di-, and tri-substituted —C1-C6alkyl(C═O)OR10 wherein the substituents are independently selected from halogen, hydroxy, amino, oxo, —COOH, —CONH2, C1-C4alkyl, C2-C4alkenyl, C2-C4alkynyl, C1-C4alkoxy, C2-C4alkanoyl, C1-C4alkylthio, C1-C2haloalkyl, C1-C2haloalkoxy, C1-C4alkoxycarbonyl, mono-C1-C4alkylamino, di-C1-C4alkylamino, mono-C1-C4alkylcarboxamide, di-C1-C4alkylcarboxamide, and phenyl,
• —C0-C6alkyl(C═O)NR10R11,
• substituted —C0-C6alkyl(C═O)NR10R11 chosen from mono-, di-, and tri-substituted —C0-C6alkyl(C═O)NR10R11 wherein the substituents are independently selected from halogen, hydroxy, amino, oxo, —COOH, —CONH2, C1-C4alkyl, C2-C4alkenyl C2-C4alkynyl, C1-C4alkoxy, C2-C4alkanoyl, C1-C4alkylthio, C1-C2haloalkyl, C1-C2haloalkoxy, C1-C4alkoxycarbonyl, mono-C1-C4alkylamino, di-C1-C4alkylamino, mono-C1-C4alkylcarboxamide, di-C1-C4alkylcarboxamide, and phenyl,
• —C1-C6alkylNR10(SO2)R11,
• substituted —C1-C6alkylNR10(SO2)R11 chosen from mono-, di-, and tri-substituted —C1-C6alkylNR10(SO2)R11 wherein the substituents are independently selected from halogen, hydroxy, amino, oxo, —COOH, —CONH2, C1-C4alkyl, C2-C4alkenyl, C2-C4alkynyl, C1-C4alkoxy, C2-C4alkanoyl, C1-C4alkylthio, C1-C2haloalkyl, C1-C2haloalkoxy, C1-C4alkoxycarbonyl, mono-C1-C4alkylamino, di-C1-C4alkylamino, mono-C1-C4alkylcarboxamide, di-C1-C4alkylcarboxamide, and phenyl,
• —C0-C6alkylNR10(C═O)R11,
• substituted —C0-C6alkylNR10(C═O)R11 chosen from mono-, di-, and tri-substituted —C0-C6alkylNR10(C═O)R11, wherein the substituents are independently selected from halogen, hydroxy, amino, oxo, —COOH, —CONH2, C1-C4alkyl, C2-C4alkenyl, C2-C4alkynyl, C1-C4alkoxy, C2-C4alkanoyl, C1-C4alkylthio, C1-C2haloalkyl, C1-C2haloalkoxy, C1-C4alkoxycarbonyl, mono-C1-C4alkylamino, di-C1-C4alkylamino, mono-C1-C4alkylcarboxamide, di-C1-C4alkylcarboxamide, and phenyl,
• —C0-C6alkyl(SO2)R10,
• substituted —C0-C6-alkyl(SO2)R10 chosen from mono-, di-, and tri-substituted —C0-C6alkyl(SO2)R10 wherein the substituents are independently selected from halogen, hydroxy, amino, oxo, —COOH, —CONH2, C1-C4alkyl, C2-C4alkenyl, C2-C4alkynyl, C1-C6alkoxy, C2-C4alkanoyl, C1-C4alkylthio, C1-C2haloalkyl, C1-C2haloalkoxy, C1-C4alkoxycarbonyl, mono-C1-C4alkylamino, di-C1-C4alkylamino, mono-C1-C4alkylcarboxamide, di-C1-C4alkylcarboxamide, and phenyl,
• —C0-C6alkylNR10(C═O)NR11R12 and
• substituted —C0-C6alkylNR10(C═O)NR11R12 chosen from mono-, di-, and tri-substituted —C0-C6alkylNR10(C═O)NR11R12, wherein the substituents are independently selected from halogen, hydroxy, amino, oxo, —COOH, —CONH2, C1-C4alkyl, C2-C4alkenyl, C2-C4alkynyl, C1-C4alkoxy, C2-C4alkanoyl, C1-C4alkylthio, C1-C2haloalkyl, C1-C2haloalkoxy, C1-C4alkoxycarbonyl, mono-C1-C4alkylamino, di-C1-C4alkylamino, mono-C1-C4alkylcarboxamide, di-C1-C4alkylcarboxamide, and phenyl, and
• -L-G, where
• L is chosen from
• C1-C2alkylene,
• substituted C1-C2alkylene chosen from mono-, di-, and tri-substituted C1-C2alkylene wherein the substituents are independently selected from halogen, hydroxy, amino, oxo, —COOH, —CONH2, C1-C4alkyl C2-C4alkenyl, C2-C4alkynyl, C1-C4alkoxy, C2-C4alkanoyl, C1-C4alkylthio, C1-C2haloalkyl, C1-C2haloalkoxy, C1-C4alkoxycarbonyl, mono-C1-C4alkylamino, di-C1-C4alkylamino, mono-C1-C4alkylcarboxamide, di-C1-C4alkylcarboxamide, and phenyl,
• C0-C2alkylene-O—,
• substituted C0-C2alkylene-O— chosen from mono-, di-, and tri-substituted C0-C2alkylene-O— wherein the substituents are independently selected from halogen, hydroxy, amino, oxo, —COOH, —CONH2, C1-C4alkyl, C2-C4alkenyl, C2-C4alkynyl, C1-C4alkoxy, C2-C4alkanoyl, C1-C4alkylthio, C1-C2haloalkyl, C1-C2haloalkoxy, C1-C4alkoxycarbonyl, mono-C1-C4alkylamino, di-C1-C4alkylamino, mono-C1-C4alkylcarboxamide, di-C1-C4alkylcarboxamide, and phenyl,
• —(C═O)—,
• —(C1-C2alkylene)(C═O)—, and
• substituted —(C1-C2alkylene)(C═O)— chosen from mono-, di-, and tri-substituted —(C1-C2alkylene)(C═O)— wherein the substituents are independently selected from halogen, hydroxy, amino, oxo, —COOH, —CONH2, C1-C4alkyl, C2-C4alkenyl, C2-C4alkynyl, C1-C4alkoxy, C2-C4alkanoyl, C1-C4alkylthio, C1-C2haloalkyl, C1-C2haloalkoxy, C1-C4alkoxycarbonyl, mono-C1-C4alkylamino, di-C1-C4alkylamino, mono-C1-C4alkylcarboxamide, di-C1-C4alkylcarboxamide, and phenyl, and
• G is chosen from
• heterocycloalkyl,
• substituted heterocycloalkyl chosen from mono-, di-, and tri-substituted heterocycloalkyl, wherein the substituents are independently selected from halogen, hydroxy, amino, oxo, —COOH, —CONH2, C1-C4alkyl, C2-C4alkenyl, C2-C4alkynyl, C1-C4alkoxy, C2-C4alkanoyl, C1-C4alkylthio, C1-C2haloalkyl, C1-C2haloalkoxy, C1-C4alkoxycarbonyl, mono-C1-C4alkylamino, di-C1-C4alkylamino, mono-C1-C4alkylcarboxamide, di-C1-C4alkylcarboxamide, and phenyl,
• C3-C7cycloalkyl,
• substituted C3-C7cycloalkyl chosen from mono-, di-, and tri-substituted C3-C7cycloalkyl wherein the substituents are independently selected from halogen, hydroxy, amino, oxo, —COOH, —CONH2, C1-C4alkyl, C2-C4alkenyl, C2-C4alkynyl, C1-C4alkoxy, C2-C4alkanoyl, C1-C4alkylthio, C1-C2haloalkyl, C1-C2haloalkoxy, C1-C4alkoxycarbonyl, mono-C1-C4alkylamino, di-C1-C4alkylamino, mono-C1-C4alkylcarboxamide, di-C1-C4alkylcarboxamide, and phenyl,
• aryl,
• substituted aryl chosen from mono-, di-, and tri-substituted aryl wherein the substituents are independently selected from halogen, hydroxy, amino, oxo, —COOH, —CONH2, C1-C4alkyl, C2-C4alkenyl, C2-C4alkynyl, C1-C4alkoxy, C2-C4alkanoyl, C1-C4alkylthio, C1-C2haloalkyl, C1-C2haloalkoxy, C1-C4alkoxycarbonyl, mono-C1-C4alkylamino, di-C1-C4alkylamino, mono-C1-C4alkylcarboxamide, di-C1-C4alkylcarboxamide, and phenyl,
• heteroaryl, and
• substituted heteroaryl chosen from mono-, di-, and tri-substituted heteroaryl wherein the substituents are independently selected from halogen, hydroxy, amino, oxo, —COOH, —CONH2, C1-C4alkyl, C2-C4alkenyl, C2-C4alkynyl, C1-C4alkoxy, C2-C4alkanoyl, C1-C4alkylthio, C1-C2haloalkyl, C1-C2haloalkoxy, C1-C4alkoxycarbonyl, mono-C1-C4alkylamino, di-C1-C4alkylamino, mono-C1-C4alkylcarboxamide, di-C1-C4alkylcarboxamide, and phenyl,
• and
• wherein R10, R11, and R12 are independently chosen from hydrogen, hydroxy, C1-C6alkyl, C1-C6alkoxy, C3-C10cycloalkyl and heterocycloalkyl, and wherein
• R1 is further optionally substituted with 1 or more substituents independently chosen from hydroxy, nitro, cyano, amino, —SO2NH2, halogen, C1-C6 alkyl, C2-C6alkanoyl, C1-C4haloalkyl, C1-C4haloalkoxy, C1-C6 alkylthio, C3-C7cycloalkyl, (C1-C6 alkoxy)C0-C6alkyl, (mono-C1-C6 alkylamino)C0-C6 alkyl, (di-C1-C6 alkylamino)C0-C6 alkyl, and C1-C6alkoxycarbonyl;
• R3 is chosen from
• hydrogen,
• halogen,
• C1-C7 alkyl,
• heterocycloalkyl,
• substituted heterocycloalkyl chosen from mono-, di-, and tri-substituted heterocycloalkyl, wherein the substituents are independently chosen from hydroxy, nitro, cyano, amino, halogen, —SO2NH2, oxo, C1-C6 alkyl, C2-C6alkenyl, C2-C6alkynyl, C1-C6 alkoxy, C1-C3haloalkyl, C1-C3haloalkoxy, C1-C6alkylthio, (C1-C6-alkoxy)C1-C6 alkoxy, mono-C1-C6alkylamino, di-C1-C6alkylamino, aminoC1-C6 alkyl, and —C(O)R14,
• C3-C7cycloalkyl,
• substituted C3-C7cycloalkyl chosen from mono-, di-, and tri-substituted C3-C7cycloalkyl, wherein the substituents are independently chosen from hydroxy, nitro, cyano, amino, halogen, —SO2NH2, oxo, C1-C6 alkyl, C2-C6alkenyl, C2-C6alkynyl, C1-C6alkoxy, C1-C3haloalkyl, C1-C3haloalkoxy, C1-C6 alkylthio, (C1-C6-alkoxy)C1-C6 alkoxy, mono-C1-C6alkylamino, di-C1-C6alkylamino, aminoC1-C6 alkyl, and —C(O)R14,
• heteroaryl, and
• substituted heteroaryl chosen from mono-, di-, and tri-substituted heteroaryl, wherein the substituents are independently chosen from hydroxy, nitro, cyano, amino, halogen, —SO2NH2, oxo, C1-C6 alkyl, C2-C6alkenyl, C2-C6alkynyl, C1-C6 alkoxy, C1-C3haloalkyl, C1-C3haloalkoxy, C1-C6 alkylthio, (C1-C6-alkoxy)C1-C6 alkoxy, mono-C1-C6alkylamino, di-C1-C6alkylamino, aminoC1-C6 alkyl, and —C(O)R14,
• Z1 is chosen from
• wherein
• R4 is chosen from
• hydrogen,
• C1-C6alkyl, which is optionally substituted with 1 or more substituents independently chosen from hydroxy, nitro, cyano, amino, halogen, oxo, C1-C6 alkyl, C2-C6alkenyl, C2-C6alkynyl, C1-C6 alkoxy, C1-C3haloalkyl, C1-C3haloalkoxy, C1-C6 alkylthio, (C1-C6alkoxy)C1-C6 alkoxy, aminoC1-C6 alkyl, mono-C1-C6 alkylamino, di-C1-C6 alkylamino, and —C(O)R14 wherein R14 is chosen from C1-C6 alkyl, C1-C3haloalkyl, and phenyl,
• C3-C7cycloalkyl, which is optionally substituted with 1 or more substituents independently chosen from hydroxy, nitro, cyano, amino, halogen, oxo, C1-C6 alkyl, C2-C6alkenyl, C2-C6alkynyl, C1-C6 alkoxy, C1-C3haloalkyl, C1-C3haloalkoxy, C1-C6 alkylthio, (C1-C6 alkoxy)C1-C6 alkoxy, aminoC1-C6 alkyl, mono-C1-C6 alkylamino, di-C1-C6 alkylamino, and —C(O)R14 wherein R14 is chosen from C1-C6 alkyl, C1-C3haloalkyl, and phenyl,
• heterocycloalkyl, which is optionally substituted with 1 or more substituents independently chosen from hydroxy, nitro, cyano, amino, halogen, oxo, C1-C6 alkyl, C2-C6alkenyl, C2-C6alkynyl, C1-C6alkoxy, C1-C3haloalkyl, C1-C3haloalkoxy, C1-C6 alkylthio, (C1-C6 alkoxy)C1-C6 alkoxy, aminoC1-C6 alkyl, mono-C1-C6 alkylamino, di-C1-C6 alkylamino, and —C(O)R14 wherein R14 is chosen from C1-C6 alkyl, C1-C3haloalkyl, and phenyl,
• phenyl, which is optionally substituted with 1 or more substituents independently chosen from hydroxy, nitro, cyano, amino, halogen, oxo, C1-C6 alkyl, C2-C6alkenyl, C2-C6alkynyl, C1-C6alkoxy, C1-C3haloalkyl, C1-C3haloalkoxy, C1-C6 alkylthio, (C1-C6 alkoxy)C1-C6 alkoxy, aminoC1-C6 alkyl, mono-C1-C6 alkylamino, di-C1-C6 alkylamino, and —C(O)R14 wherein R14 is chosen from C1-C6alkyl, C1-C3haloalkyl, and phenyl, and
• heteroaryl, which is optionally substituted with 1 or more substituents independently chosen from hydroxy, nitro, cyano, amino, halogen, oxo, C1-C6 alkyl, C2-C6alkenyl, C2-C6 alkynyl, C1-C6 alkoxy, C1-C3haloalkyl, C1-C3haloalkoxy, C1-C6 alkylthio, (C1-C6 alkoxy)C1-C6 alkoxy, aminoC1-C6 alkyl, mono-C1-C6 alkylamino, di-C1-C6 alkylamino, and —C(O)R14 wherein R14 is chosen from C1-C6 alkyl, C1-C3haloalkyl, and phenyl,
• and
• R5 is chosen from isopropyl and t-butyl.

The compound, which is

• 4-tert-Butyl-N-[3-(8-phenylamino-imidazo[1,2-a]pyrazin-6-yl)-phenyl]-benzamide;
• 4-Isopropyl-N-[3-(8-phenylamino-imidazo[1,2-a]pyrazin-6-yl)-phenyl]-benzamide;
• 4-tert-Butyl-N-{3-[8-(pyridin-3-ylamino)-imidazo[1,2-a]pyrazin-6-yl]-phenyl}-benzamide;
• 4-tert-Butyl-N-{3-[8-(4-methoxy-phenylamino)-imidazo[1,2-a]pyrazin-6-yl]-phenyl}-benzamide;
• 4-tert-Butyl-N-{3-[8-(pyridin-4-ylamino)-imidazo[1,2-a]pyrazin-6-yl]-phenyl}-benzamide;
• 4-tert-Butyl-N-{3-[8-(4-fluoro-phenylamino)-imidazo[1,2-a]pyrazin-6-yl]-phenyl}-benzamide;
• 4-tert-Butyl-N-{3-[8-(3-fluoro-phenylamino)-imidazo[1,2-a]pyrazin-6-yl]-phenyl}-benzamide;
• 4-{6-[3-(4-tert-Butyl-benzoylamino)-phenyl]-imidazo[1,2-a]pyrazin-8-ylamino}-benzoic acid;
• 4-tert-Butyl-N-{3-[8-(3-methoxy-phenylamino)-imidazo[1,2-a]pyrazin-6-yl]-phenyl}-benzamide
• 4-tert-Butyl-N-{3-[8-(6-methoxy-pyridin-3-ylamino)-imidazo[1,2-a]pyrazin-6-yl]-phenyl}-benzamide;
• 3-{6-[3-(4-tert-Butyl-benzoylamino)-phenyl]-imidazo[1,2-a]pyrazin-8-ylamino}-benzoic acid
• 4-{6-[3-(4-Isopropyl-benzoylamino)-phenyl]-imidazo[1,2-a]pyrazin-8-ylamino}-benzoic acid;
• 4-tert-Butyl-N-{3-[8-(4-cyano-phenylamino)-imidazo[1,2-a]pyrazin-6-yl]-phenyl}-benzamide;
• 4-{6-[3-(4-tert-Butyl-benzoylamino)-phenyl]-imidazo[1,2-a]pyrazin-8-ylamino}-benzamide;
• 4-tert-Butyl-N-{3-[8-(4-morpholin-4-yl-phenylamino)-imidazo[1,2-a]pyrazin-6-yl]-phenyl}-benzamide;
• 3-{6-[3-(4-tert-Butyl-benzoylamino)-phenyl]-imidazo[1,2-a]pyrazin-8-ylamino}-benzoic acid;
• 4-tert-Butyl-N-{3-[8-(3-fluoro-4-methoxy-phenylamino)-imidazo[1,2-a]pyrazin-6-yl]-phenyl}-benzamide;
• 4-{6-[3-(4-tert-Butyl-benzoylamino)-phenyl]-imidazo[1,2-a]pyrazin-8-ylamino}-benzoic N-Methyl amide;
• 4-tert-Butyl-N-{3-[8-(4-piperazin-1-yl-phenylamino)-imidazo[1,2-a]pyrazin-6-yl]-phenyl}-benzamide;
• 4-tert-Butyl-N-[3-(8-m-tolylamino-imidazo[1,2-a]pyrazin-6-yl)-phenyl]-benzamide;
• (4-{6-[3-(4-tert-Butyl-benzoylamino)-phenyl]-imidazo[1,2-a]pyrazin-8-ylamino}-phenyl)-acetic acid methyl ester;
• (4-{6-[3-(4-tert-Butyl-benzoylamino)-phenyl]-imidazo[1,2-a]pyrazin-8-ylamino}-phenyl)-acetic acid;
• 4-tert-Butyl-N-(3-{8-[4-(piperazine-1-carbonyl)-phenylamino]-imidazo[1,2-a]pyrazin-6-yl}-phenyl)-benzamide;
• 4-tert-Butyl-N-(3-{8-[4-(2-methoxy-ethoxymethoxy)-phenylamino]-imidazo[1,2-a]pyrazin-6-yl}-phenyl)-benzamide;
• 4-tert-Butyl-N-{3-[8-(6-piperazin-1-yl-pyridin-3-ylamino)-imidazo[1,2-a]pyrazin-6-yl]-phenyl}-benzamide;
• 4-tert-Butyl-N-(3-{8-[4-(4-methyl-piperazin-1-yl)-phenylamino]-imidazo[1,2-a]pyrazin-6-yl}-phenyl)-benzamide;
• 4-tert-Butyl-N-{3-[8-(4-[1,4]diazepan-1-yl-phenylamino)-imidazo[1,2-a]pyrazin-6-yl]-phenyl}-benzamide;
• 4-tert-Butyl-N-(3-{8-[4-(4-oxo-piperidin-1-yl)-phenylamino]-imidazo[1,2-a]pyrazin-6yl}-phenyl)-benzamide;
• (4-{6-[3-(4-tert-Butyl-benzoylamino)-phenyl]-imidazo[1,2-a]pyrazin-8-ylamino}-benzoylamino)-acetic acid methyl ester;
• (4-{6-[3-(4-tert-Butyl-benzoylamino)-phenyl]-imidazo[1,2-a]pyrazin-8-ylamino}-benzoylamino)-acetic acid;
• N-(3-{8-[4-(4-Acetyl-piperazin-1-yl)-phenylamino]-imidazo[1,2-a]pyrazin-6-yl}-phenyl)-4-tert-butyl-benzamide;
• 4-tert-Butyl-N-(3-{8-[4-(3-methyl-piperazin-1-yl)-phenylamino]-imidazo[1,2-a]pyrazin-6-yl}phenyl)-benzamide;
• 4-{6-[3-(4-tert-Butyl-benzoylamino)-phenyl]-imidazo[1,2-a]pyrazin-8-ylamino}-benzoic hydroxyl amide;
• 4-tert-Butyl-N-{3-[8-(4-hydroxymethyl-phenylamino)-imidazo[1,2-a]pyrazin-6-yl]-phenyl}-benzamide;
• 4-tert-Butyl-N-{3-[8-(4-piperazin-1-ylmethyl-phenylamino)-imidazo[1,2-a]pyrazin-6-yl]-phenyl}-benzamide;
• 4-{6-[3-(4-Bromo-3-methyl-benzoylamino)-phenyl]-imidazo[1,2-a]pyrazin-8-ylamino}-benzoic acid;
• 4-tert-Butyl-N-{3-[8-(3-methyl-4-piperazin-1-yl-phenylamino)-imidazo[1,2-a]pyrazin-6-yl]-phenyl}-benzamide;
• 4-tert-Butyl-N-(3-{8-[4-(3-methyl-piperazin-1-yl)-phenylamino]-imidazo[1,2-a]pyrazin-6-yl}-phenyl)-benzamide;
• 4-tert-Butyl-N-{3-[8-(3-hydroxymethyl-phenylamino)-imidazo[1,2-a]pyrazin-6-yl]-phenyl}-benzamide;
• 4-tert-Butyl-N-(3-{8-[3-(3-methyl-piperazin-1-ylmethyl)-phenylamino]-imidazo[1,2-a]pyrazin-6-yl}-phenyl)-benzamide;
• 4-tert-Butyl-N-(3-{8-[3-(3,5-dimethyl-piperazin-1-ylmethyl)-phenylamino]-imidazo[1,2-a]pyrazin-6-yl}-phenyl)-benzamide;
• 4-tert-Butyl-N-(3-{8-[3-(3,5-dimethyl-piperazin-1-ylmethyl)-phenylamino]-imidazo[1,2-a]pyrazin-6-yl}-phenyl)-benzamide;
• 4-tert-Butyl-N-(3-{8-[4-(3,5-dimethyl-piperazin-1-yl)-phenylamino]-imidazo[1,2-a]pyrazin-6-yl}-phenyl)-benzamide;
• 4-({6-[3-(4-tert-Butyl-benzoylamino)-phenyl]-imidazo[1,2-a]pyrazin-8-ylamino}-methyl) -benzoic acid;
• 4-tert-Butyl-N-(3-{8-[4-(3-methyl-piperazin-1-yl)-phenylamino]-imidazo[1,2-a]pyrazin-6-yl}-phenyl)-benzamide;
• 4-(1-Hydroxy-1-methyl-ethyl)-N-[3-(8-phenylamino-imidazo[1,2-a]pyrazin-6-yl)-phenyl]-benzamide;
• (3-{6-[3-(4-tert-Butyl-benzoylamino)-phenyl]-imidazo[1,2-a]pyrazin-8-ylamino}-phenyl) -acetic acid;
• N-[3-(8-Phenylamino-imidazo[1,2-a]pyrazin-6-yl)-phenyl]-terephthalamic acid methyl ester;
• N-[3-(8-Phenylamino-imidazo[1,2-a]pyrazin-6-yl)-phenyl]-terephthalamic acid;
• 2-(4-{6-[3-(4-tert-Butyl-benzoylamino)-phenyl]-imidazo[1,2-a]pyrazin-8-ylamino}-phenyl)-propionic acid ethyl ester;
• 2-(4-{6-[3-(4-tert-Butyl-benzoylamino)-phenyl]-imidazo[1,2-a]pyrazin-8-ylamino}-phenyl)-propionic acid;
• 4-{6-[3-(4-tert-Butyl-benzoylamino)-phenyl]-imidazo[1,2-a]pyrazin-8-ylamino}-2-methoxy-benzoic acid methyl ester;
• 4-{6-[3-(4-tert-Butyl-benzoylamino)-phenyl]-imidazo[1,2-a]pyrazin-8-ylamino}-2-methoxy-benzoic acid;
• 4-tert-Butyl-N-{3-[8-(3-methylcarbamoylmethyl-phenylamino)-imidazo[1,2-a]pyrazin-6-yl]-phenyl}-benzamide;
• 4-tert-Butyl-N-{3-[8-(4-methylcarbamoylmethyl-phenylamino)-imidazo[1,2-a]pyrazin-6-yl]-phenyl}-benzamide;
• 4-tert-Butyl-N-{3-[8-(4-cyclooctylcarbamoylmethyl-phenylamino)-imidazo[1,2-a]pyrazin-6-yl]-phenyl}-benzamide;
• 4-tert-Butyl-N-[3-(8-{4[(diisopropylcarbamoyl)-methyl]-phenylamino}-imidazo[1,2-a]pyrazin-6-yl)-phenyl]-benzamide;
• 4-tert-Butyl-N-{3-[8-(4-carbamoylmethyl-phenylamino)-imidazo[1,2-a]pyrazin-6-yl]-phenyl}-benzamide;
• 3-(4-{6-[3-(4-tert-Butyl-benzoylamino)-phenyl]-imidazo[1,2-a]pyrazin-8-ylamino}-phenyl)-propionic acid;
• 4-tert-Butyl-N-(3-{8-[4-(2-hydroxy-ethyl)-phenylamino]-imidazo[1,2-a]pyrazin-6-yl}-phenyl)-benzamide;
• 4-tert-Butyl-N-(3-{8-[4-(2-methylamino-ethyl)-phenylamino]-imidazo[1,2-a]pyrazin-6-yl}-phenyl)-benzamide;
• 4-tert-Butyl-N-{3-[8-(4-methylaminomethyl-phenylamino)-imidazo[1,2-a]pyrazin-6-yl]-phenyl}-benzamide;
• 4-{6-[3-(4-tert-Butyl-benzoylamino)-phenyl]-imidazo[1,2-a]pyrazin-8-ylamino}-2-hydroxy-benzoic acid;
• 4-tert-Butyl-N-(3-{8-[4-(1-hydroxy-1-methyl-ethyl)-phenylamino]-imidazo[1,2-a]pyrazin-6-yl}-phenyl)-benzamide;
• 4-tert-Butyl-N-(3-{8-[4-(2-hydroxy-ethoxy)-phenylamino]-imidazo[1,2-a]pyrazin-6-yl}phenyl)-benzamide;
• 4-tert-Butyl-N-(3-{8-[4-(4-methyl-piperazine-1-carbonyl)-phenylamino]-imidazo[1,2-a]pyrazin-6-yl}-phenyl)-benzamide;
• 4-tert-Butyl-N-(3-{8-[4-(2-methylamino-ethoxy)-phenylamino]-imidazo[1,2-a]pyrazin-6-yl}-phenyl)-benzamide;
• 4-tert-Butyl-N-(3-{8-[4-(2-dimethylamino-ethoxy)-phenylamino]-imidazo[1,2-a]pyrazin-6-yl}-phenyl)-benzamide;
• 4-{6-[3-(4-tert-Butyl-benzoylamino)-phenyl]-imidazo[1,2-a]pyrazin-8-ylamino}-benzoic methoxy amide;
• 4-{6-[3-(4-tert-Butyl-benzoylamino)-phenyl]-imidazo[1,2-a]pyrazin-8-ylamino}-benzoic hyrdoxyl methyl amide;
• 4-tert-Butyl-N-(3-{8-[4-([1,4]diazepane-1-carbonyl)-phenylamino]-imidazo[1,2-a]pyrazin-6-yl}-phenyl)-benzamide;
• 4-tert-Butyl-N-(3-{8-[4-(pyrrolidine-1-carbonyl)-phenylamino]-imidazo[1,2-a]pyrazin-6-yl}-phenyl)-benzamide;
• 4-tert-Butyl-N-(3-{8-[4-(morpholine-4-carbonyl)-phenylamino]-imidazo[1,2-a]pyrazin-6-yl}-phenyl)-benzamide;
• 4-tert-Butyl-N-(3-{8-[4-(ethoxyamine-4-carbonyl)-phenylamino]-imidazo[1,2-a]pyrazin-6-yl}-phenyl)-benzamide;
• 4-tert-Butyl-N-(3-{8-[4-(dimethylamine-4-carbonyl)-phenylamino]-imidazo[1,2-a]pyrazin-6}-phenyl)-benzamide;
• 4-tert-Butyl-N-(3-{8-[4-(methylethylamine-4-carbonyl)-phenylamino]-imidazo[1,2-a]pyrazin-6-yl}-phenyl)-benzamide;
• 4-tert-Butyl-N-(3-{8-[4-(3-oxo-piperazine-1-carbonyl)-phenylamino]-imidazo[1,2-a]pyrazin-6-yl}-phenyl)-benzamide;
• 4-tert-Butyl-N-(3-{8[N,N,N′-Trimethyl-ethane-1,2-diamine-4-carbonyl)-phenylamino]-imidazo[1,2-a]pyrazin-6-yl}-phenyl)-benzamide;
• 4-tert-Butyl-N-(3-{8-[4-(4-methyl-[1,4]diazepane-1-carbonyl)-phenylamino]-imidazo[1,2-a]pyrazin-6-yl}-phenyl)-benzamide;
• 4-tert-Butyl-N-(3-{8-[4-(N-methyl ethoxyamine-4-carbonyl)-phenylamino]-imidazo[1,2-a]pyrazin-6-yl}-phenyl)-benzamide;
• 4-tert-Butyl-N-(3-{8-[4-(4-ethyl-piperazine-1-carbonyl)-phenylamino]-imidazo[1,2-a]pyrazin-6-yl}-phenyl)-benzamide;
• 4-{6-[3-(4-tert-Butyl-benzoylamino)-phenyl]-imidazo[1,2-a]pyrazin-8-ylamino}-benzoic benzyl amide;
• 4-tert-Butyl-N-(3-{8-[4-(4-methyl-piperazin-1-ylmethyl)-phenylamino]-imidazo[1,2-a]pyrazin-6-yl}-phenyl)-benzamide;
• 4-tert-Butyl-N-(3-{8-[4-(4-ethyl-piperazin-1-ylmethyl)-phenylamino]-imidazo[1,2-a]pyrazin-6-yl}-phenyl)-benzamide;
• 4-tert-Butyl-N-{3-[8-(4-[1,4]diazepan-1-ylmethyl-phenylamino)-imidazo[1,2-a]pyrazin-6-yl]-phenyl}-benzamide;
• 4-tert-Butyl-N-(3-{8-[4-(3-methyl-piperazin-1-ylmethyl)-phenylamino]-imidazo[1,2-a]pyrazin-6-yl}-phenyl)-benzamide;
• 4-tert-Butyl-N-{3-[8-(4-dimethylaminomethyl-phenylamino)-imidazo[1,2-a]pyrazin-6-yl]-phenyl}-benzamide;
• 4-tert-Butyl-N-[3-(8-{4[(ethyl-methyl-amino)-methyl]-phenylamino}-imidazo[1,2-a]pyrazin-6-yl)-phenyl]-benzamide;
• 4-tert-Butyl-N-{3-[8-(4-{[(2-methoxy-ethyl)-methyl-amino]-methyl}-phenylamino)-imidazo[1,2-a]pyrazin-6-yl]-phenyl}-benzamide;
• 4-tert-Butyl-N-[3-(8-{4[(2-methoxy-ethylamino)-methyl]-phenylamino}-imidazo[1,2-a]pyrazin-6-yl)-phenyl]-benzamide;
• 4-tert-Butyl-N-{3-[8-(4-{ [(2-dimethylamino-ethyl)-methyl-amino]-methyl}-phenylamino) -imidazo[1,2-a]pyrazin-6-yl]-phenyl}-benzamide;
• N-(3-{8-[4-(4-Acetyl-piperazine-1-carbonyl)-phenylamino]-imidazo[1,2-a]pyrazin-6-yl}-phenyl)-4-tert-butyl-benzamide;
• 4-tert-Butyl-N-{3-[8-(4-{[(2-hydroxy-ethyl)-methyl-amino]-methyl}-phenylamino)-imidazo[1,2-a]pyrazin-6-yl]-phenyl}-benzamide;
• 4-tert-Butyl-N-[3-(8-{4[(2-hydroxy-ethylamino)-methyl]-phenylamino}-imidazo[1,2-a]pyrazin-6-yl)-phenyl]-benzamide;
• 4-tert-Butyl-N-(3-{8-[4-(4-methyl-[1,4]diazepan-1-ylmethyl)-phenylamino]-imidazo[1,2-a]pyrazin-6-yl}-phenyl)-benzamide;
• N-[3-(8-{4-[2-(Acetyl-methyl-amino)-ethoxy]-phenylamino}-imidazo[1,2-a]pyrazin-6-yl) -phenyl]-4-tert-butyl-benzamide;
• 4-(4-{6-[3-(4-tert-Butyl-benzoylamino)-phenyl]-imidazo[1,2-a]pyrazin-8-ylamino}-phenyl)-piperazine-1-carboxylic acid ethyl ester;
• N-(3-{8-[4-(4-Acetyl-piperazin-1-ylmethyl)-phenylamino]-imidazo[1,2-a]pyrazin-6-yl}-phenyl-4-tert-butyl-benzamide;
• 4-tert-Butyl-N-{3-[8-(4-imidazol-1-ylmethyl-phenylamino)-imidazo[1,2-a]pyrazin-6-yl]-phenyl}-benzamide;
• 4-tert-Butyl-N-{3-[8-(4-pyrrolidin-1-ylmethyl-phenylamino)-imidazo[1,2-a]pyrazin-6-yl]-phenyl}-benzamide;
• N-[3-(8-{4[(Acetyl-methyl-amino)-methyl]-phenylamino}-imidazo[1,2-a]pyrazin-6-yl)-phenyl]-4-tert-butyl-benzamide;
• 4-tert-Butyl-N-[3-(8-{4[(methanesulfonyl-methyl-amino)-methyl]-phenylamino}-imidazo[1,2-a]pyrazin-6-yl)-phenyl]-benzamide;
• 4-tert-Butyl-N-(3-{8-[4-(3-isopropyl-1-methyl-ureidomethyl)-phenylamino]-imidazo[1,2-a]pyrazin-6-yl}-phenyl)-benzamide;
• 4-Isopropyl-N-(3-{8-[4-(morpholine-4-carbonyl)-phenylamino]-imidazo[1,2-a]pyrazin-6-yl}-phenyl)-benzamide;
• N-}3-[8-(4-}[(2-Hydroxy-ethyl)-methyl-amino]-carbonyl}-phenylamino)-imidazo[1,2-a]pyrazin-6yl]-phenyl}-4-isopropyl-benzamide;
• N-(3-{8-[4-(Morpholine-4-carbonyl)-phenylamino]-imidazo[1,2-a]pyrazin-6-yl}-phenyl)-benzamide;
• 4-Methyl-N-(3-{8-[4-(morpholine-4-carbonyl)-phenylamino]-imidazo[1,2-a]pyrazin-6-yl}-phenyl)-benzamide;
• 4-Ethyl-N-(3-{8-[4-(morpholine-4-carbonyl)-phenylamino]-imidazo[1,2-a]pyrazin-6-yl}-phenyl)-benzamide;
• 4-Fluoro-N-(3-{8-[4-(morpholine-4-carbonyl)-phenylamino]-imidazo[1,2-a]pyrazin-6-yl}-phenyl)-benzamide;
• N-(3-{8-[4-(Morpholine-4-carbonyl)-phenylamino]-imidazo[1,2-a]pyrazin-6-yl}-phenyl)-4-trifluoromethyl-benzamide;
• 4-tert-Butyl-N-(3-{8-[4-(5,6-dihydro-8H-imidazo[1,2-a]pyrazine-7-carbonyl)-phenylamino]imidazo[1,2-a]pyrazin-6-yl}-phenyl)-benzamide;
• 4-tert-Butyl-N-(3-{8-[4-(3-oxo-piperazin-1-ylmethyl)-phenylamino]-imidazo[1,2-a]pyrazin-6-yl}-phenyl)-benzamide;
• 1-(4-{6-[3-(4-tert-Butyl-benzoylamino)-phenyl]-imidazo[1,2-a]pyrazin-8-ylamino}-benzyl)-pyrrolidine-2-carboxylic acid methyl ester;
• N-(3-{8-[4-(Morpholine-4-carbonyl)-phenylamino]-imidazo[1,2-a]pyrazin-6-yl}-phenyl) -terephthalamic acid methyl ester;
• N-(3-{8-[4-(Morpholine-4-carbonyl)-phenylamino]-imidazo[1,2-a]pyrazin-6-yl}-phenyl) -terephthalamic acid;
• N-(3-{8-[4-(4-Acetyl-piperazin-1-yl)-phenylamino]-imidazo[1,2-a]pyrazin-6-yl}-phenyl)-4-ethyl-benzamide;
• N-(3-{8-[4-(4-Acetyl-piperazin-1-yl)-phenylamino]-imidazo[1,2-a]pyrazin-6-yl}-phenyl)-4-trifluoromethyl-benzamide;
• 4-tert-Butyl-N-(3-{8-[4-(3-methyl-5,6-dihydro-8H-[1,2,4]triazolo[4,3-a]pyrazin-7-ylmethyl-phenylamino]-imidazo[1,2-a]pyrazin-6-yl}-phenyl)-benzamide;
• 4-tert-Butyl-N-(3-{8-[4-(3-methyl-5,6-dihydro-8H-[1,2,4]triazolo[4,3-a]pyrazine-7-carbonyl)-phenylamino]-imidazo[1,2-a]pyrazin-6-yl}-phenyl)-benzamide;
• N-(3-{8-[4-(4-Acetyl-piperazin-1-yl)-phenylamino]-imidazo[1,2-a]pyrazin-6-yl}-phenyl)-4-isopropyl-benzamide;
• N-(3-{8-[4-(4-Acetyl-piperazine-1-carbonyl)-phenylamino]-imidazo[1,2-a]pyrazin-6-yl}phenyl)-4-isopropyl-benzamide;
• 1-(4-{6-[3-(4-tert-Butyl-benzoylamino)-phenyl]-imidazo[1,2-a]pyrazin-8-ylamino}-benzyl)-pyrrolidine-2-carboxylic acid;
• 4-Isopropyl-N-(3-{8-[4-(3-methyl-5,6-dihydro-8H-[1,2,4]triazolo[4,3-a]pyrazine-7-carbonyl)-phenylamino]-imidazo[1,2-a]pyrazin-6-yl}-phenyl)-benzamide;
• N-(3-{8-[4-(5,6-Dihydro-8H-imidazo[1,2-a]pyrazine-7-carbonyl)-phenylamino]-imidazo[1,2-a]pyrazin-6-yl}-phenyl)-4-isopropyl-benzamide;
• 4-Isopropyl-N-(3-{8-[4-(3-oxo-piperazine-1-carbonyl)-phenylamino]-imidazo[1,2-a]pyrazin-6-yl}-phenyl)-benzamide;
• 4-Isopropyl-N-(3-{8-[4-(4-methyl-piperazine-1-carbonyl)-phenylamino]-imidazo[1,2-a]pyrazin-6-yl}-phenyl)-benzamide;
• 4-Isopropyl-N-(3-{8-[4-(3-oxo-piperazin-1-ylmethyl)-phenylamino]-imidazo[1,2-a]pyrazin -6-yl}-phenyl)-benzamide;
• N-(3-{8-[4-(4-Acetyl-piperazin-1-ylmethyl)-phenylamino]-imidazo[1,2-a]pyrazin-6-yl}-phenyl)-4-isopropyl-benzamide;
• N-(3-{8-[4-(Morpholine-4-carbonyl)-phenylamino]-imidazo[1,2-a]pyrazin-6-yl}-phenyl) -isonicotinamide:
• N-(3-{8-[4-(Morpholine-4-carbonyl)-phenylamino]-imidazo[1,2-a]pyrazin-6-yl}-phenyl) -nicotinamide;
• 4-tert-Butyl-N-(3-{8-[4-(2-morpholin-4-yl-2-oxo-ethyl)-phenylamino]-imidazo[1,2-a]pyrazin-6-yl}-phenyl)-benzamide;
• 4-tert-Butyl-N-(3-{8-[3-(2-morpholin-4-yl-2-oxo-ethyl)-phenylamino]-imidazo[1,2-a]pyrazin-6-yl}-phenyl)-benzamide;
• 4-Isopropyl-N-{3-[8-(4-morpholin-4-ylmethyl-phenylamino)-imidazo[1,2-a]pyrazin-6-yl]-phenyl}-benzamide;
• 4-tert-Butyl-N-{3-[8-(4-morpholin-4-ylmethyl-phenylamino)-imidazo[1,2-a]pyrazin-6-yl]-phenyl}-benzamide;
• N-(3-{8-[4-(Morpholine-4-carbonyl)-phenylamino]-imidazo[1,2-a]pyrazin-6-yl}-phenyl)-2-phenyl-acetamide;
• N-(4-tert-Butyl-phenyl)-3-}8-[4-(morpholine-4-carbonyl)-phenylamino]-imidazo[1,2-a]pyrazin-6-yl}-benzamide;
• N-(3-Chloro-benzyl)-3-{8-[4-(morpholine-4-carbonyl)-phenylamino]-imidazo[1,2-a]pyrazin-6-yl}-benzamide;
• 4-Cyano-N-(3-{8-[4-(morpholine-4-carbonyl)-phenylamino]-imidazo[1,2-a]pyrazin-6-yl}-phenyl)-benzamide;
• 6-Dimethylamino-N-(3-{8-[4-(morpholine-4-carbonyl)-phenylamino]-imidazo[1,2-a]pyrazin-6-yl}-phenyl)-nicotinamide;
• N-Methyl-N′-(3-{8-[4-(morpholine-4-carbonyl)-phenylamino]-imidazo[1,2-a]pyrazin-6-yl}-phenyl)-terephthalamide;
• N,N-Dimethyl-N′-(3-{8-[4-(morpholine-4-carbonyl)-phenylamino]-imidazo[1,2-a]pyrazin-6-yl}-phenyl)-terephthalamide;
• 4-Acetyl-N-(3-{8-[4-(morpholine-4-carbonyl)-phenylamino]-imidazo[1,2-a]pyrazin-6-yl}-phenyl)-benzamide;
• 4-(1H-Imidazol-2-yl)-N-(3-{8-[4-(morpholine-4-carbonyl)-phenylamino]-imidazo[1,2-a]pyrazin-6-yl}-phenyl)-benzamide;
• 2-(3-Isopropyl-phenoxy)-N-(3-{8-[4-(morpholine-4-carbonyl)-phenylamino]-imidazo[1,2-a]pyrazin-6-yl}-phenyl)-acetamide;
• 6-tert-Butyl-N-(3-{8-[4-(morpholine-4-carbonyl)-phenylamino]-imidazo[1,2-a]pyrazin-6-yl}-phenyl)-nicotinamide;
• or
• 4-(6-{3[(6-tert-Butyl-pyridine-3-carbonyl)-amino]-phenyl}-imidazo[1,2a]pyrazin-8-ylamino)-benzoic acid
• or a pharmaceutically acceptable salt, hydrate or diastereomer thereof.