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US 7,405,292 B2Granted
Cellular genes regulated by HIV-1 infection and methods of use thereof
AssigneeThe Children's Hospital of Philadelphia
InventorsTerri H. Finkel, Jiyi Yin
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Abstract
This invention provides cellular gene products which have anti-apoptotic activity in HIV-1 infected cells and provides agents for the inhibition of the cellular gene products.
Claims12
An isolated small, interfering RNA (siRNA) molecule targeted to a nucleic acid molecule encoding HIV-Associated Life Preserver (HALP), wherein said siRNA molecule inhibits expression of HALP protein upon entry into a cell comprising HALP encoding nucleic acids, wherein the sequence of the sense strand of said siRNA molecule is SEQ ID NO:
- 21.
Dependencies are inferred from the claim text.