Pancreatic islet transcription factor and uses thereof

An isolated nucleic acid encoding a polypeptide comprising in the following order:

• a proline/glutamine rich domain, an RFX DNA binding domain (SEQ ID NO:4), an RFX B domain (SEQ ID NO:5), an RFX C domain (SEQ ID NO:6), a dimerization domain (SEQ ID NO:7) and a serine/threonine domain.

A method of detecting a polynucleotide in a subject, the method comprising

• detecting in a sample from the subject a polynucleotide encoding a polypeptide comprising in the following order:
• a proline/glutamine rich domain, an RFX DNA binding domain (SEQ ID NO:4), an RFX B domain (SEQ ID NO:5), an RFX C domain (SEQ ID NO:6), a dimerization domain (SEQ ID NO:7) and a serine/threonine domain.

A method of introducing an expression cassette into an isolated cell, the method comprising,

• introducing into the cell an expression cassette comprising a promoter operably linked to a polynucleotide encoding a polypeptide, the polypeptide comprising in the following order:
• a proline/glutamine rich domain, an RFX DNA binding domain (SEQ ID NO:4), an RFX B domain (SEQ ID NO:5), an FRX C domain (SEQ ID NO:6), a dimerization domain (SEQ ID NO:7) and a serine/threonine domain.