Connective tissue growth factor antibodies
AssigneeFibroGen, Inc.
InventorsAl Y. Lin, Thomas B. Neff, Noelynn A. Oliver, William R. Usinger, Qingjian Wang, David A. Yeowell
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Abstract
The present invention relates to antibodies that bind to CTGF. The antibodies are particularly directed to regions of CTGF involved in biological activities associated with fibrosis. The invention also relates to methods of using the antibodies to treat disorders associated with CTGF including localized and systemic fibrotic disorders including those of the lung, liver, heart, skin, and kidney.
Claims28
An isolated antibody comprising at least one polypeptide selected from the group consisting of:
- (a) a heavy chain having the amino acid sequence of SEQ ID NO:
- 14;
- (b) a light chain having the amino acid sequence of SEQ ID NO:20;
- and
- (c) an immunoglobulin fragment comprising a variable domain of (a) or (b) wherein the antibody or fragment binds connective tissue growth factor (CTGF).
An isolated antibody, comprising an immunoglobulin heavy chain having the amino acid sequence as set forth in SEQ ID NO:14 and an immunoglobulin light chain having the amino acid sequence as set forth in SEQ ID NO:20.
An isolated antibody comprising the antibody produced by the cell line identified by ATCC Accession No. PTA-6006.
An isolated antibody comprising:
- (a) a heavy chain comprising the amino acid sequence of SEQ ID NO:14 or a fragment of the amino acid sequence of SEQ ID NO:14 from amino acid 1 through amino acid 167;
- and
- (b) a light chain comprising the amino acid sequence of SEQ ID NO:20 or a fragment of the amino acid sequence of SEQ ID NO:20 from amino acid 1 through amino acid 136 wherein the antibody or fragment binds CTGF.
Dependencies are inferred from the claim text.