Chimeric immunogens
AssigneeSanofi Pasteur Limited
InventorsMichel H. Klein, Run-Pan Du, Mary E. Ewasyshyn
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Abstract
Multimeric hybrid genes encoding the corresponding chimeric protein comprise a gene sequence coding for an antigenic region of a protein from a first pathogen linked to a gene sequence coding for an antigenic region of a protein from a second pathogen. The pathogens particularly are parainfluenza virus (PIV) and respiratory syncytial virus (RSV). A single recombinant immunogen is capable of protecting infants and similar susceptible individuals against diseases caused by both PIV and RSV.
Claims2
A chimeric protein including a protein from parainfluenza virus (PIV) and a protein from respiratory syncytial virus (RSV), which comprises a PIV-3 F protein or a fragment thereof having fusion activity linked to a RSV F protein or a fragment thereof having fusion activity.
Dependencies are inferred from the claim text.