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AssigneeGenetics Institute, Inc.
InventorsMeike Lorenz, Ron Kriz, Nadine Weich, Gray D. Shaw
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The invention provides isolated nucleic acids molecules, designated SLIC-1 nucleic acid molecules, which encode novel P-selectin glycoprotein ligand (PSGL-1) binding molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing SLIC-1 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a SLIC-1 gene has been introduced or disrupted. The invention still further provides isolated SLIC-1 proteins, fusion proteins, antigenic peptides and anti-SLIC-1 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
An isolated polypeptide comprising the amino acid sequence set forth in SEQ ID NO:2, wherein the polypeptide binds or interacts with the cytoplasmic domain of a PSGL-1 protein.
An isolated polypeptide comprising a fragment of the amino acid sequence set forth in SEQ ID NO:2, wherein the polypeptide binds or interacts with the cytoplasmic domain of a PSGL-1 protein, and wherein the fragment comprises at least amino acids 1-226 of SEQ ID NO:2.
An isolated polypeptide encoded by a nucleic acid molecule comprising a nucleotide sequence set forth in SEQ ID NQ:1, wherein the polypeptide binds or interacts with the cytoplasmic domain of a PSGL-1 protein.
A polypeptide comprising amino acids 1-226 of SEQ ID NO:2, which is encoded by a nucleic acid molecule comprising a nucleotide sequence which is at least 95% identical to a nucleic acid comprising the nucleotide sequence set forth in SEQ ID NO:1, wherein the polypeptide binds or interacts with the cytoplasmic domain of a PSGL-1 protein.
A polypeptide comprising amino acids 1-226 of SEQ ID NO:2, wherein the polypeptide is at least 95% identical to the amino acid sequence set forth in SEQ ID NO:2, wherein the polypeptide binds or interacts with the cytoplasmic domain of a PSGL-1 protein.
Dependencies are inferred from the claim text.