Indole derivatives comprising an acetylene group

A compound of the formula (I):

• wherein:
• R1 is hydrogen or C1-7-alkyl;
• R2 and R3 independently from each other are selected from the group consisting of hydrogen, C1-7-alkyl and C1-7-alkyl-C1-7-alkoxy;
• R4 and R5 independently from each other are selected from the group consisting of hydrogen, C1-7-alkyl, C3-7-cycloalkyl, halogen, C1-7-alkoxy-C1-7-alkyl, C2-7-alkenyl, C2-7-alkinyl, fluoro-C1-7-alkyl, fluoro-C1-7-alkoxy, cyano-C1-7-alkyl and cyano;
• R6, R7, R8 and R9 independently from each other are selected from the group consisting of hydrogen, C1-7-alkyl, C3-7-cycloalkyl, halogen, C1-7-alkoxy-C1-7-alkyl, C2-7-alkenyl, C2-7-alkinyl, fluoro-C1-7-alkyl, fluoro-C1-7-alkoxy, cyano-C1-7-alkyl and cyano;
• and one of R6, R7, R8 and R9 is
• wherein:
• X is selected from the group consisting of S, O, NR13, (CH2)pNR13CO and (CH2)pCONR13,
• R13 is selected from the group consisting of hydrogen, C1-7-alkyl, C3-7-cycloalkyl, fluoro-C1-7-alkyl, hydroxy-C2-7-alkyl and C1-7-alkoxy-C2-7-alkyl;
• R10 is selected from the group consisting of C1-7-alkyl, C3-7-cycloalkyl, fluoro-C1-7-aklyl and C1-7-alkoxy-C1-7-alkyl;
• R11 is selected from the group consisting of hydrogen, C1-7-alkyl and C1-7-alkoxy-C1-7-alkyl;
• or R10 and R11 together with the carbon atom they are attached to form a C3-6-cycloalkyl ring;
• R12 is aryl or heteroaryl;
• m, o, p is 0, 1 or 2;
• n is 0, 1, 2 or 3 and the sum of m, n and o is 1 to 5;
• and
• pharmaceutically acceptable salts and/or esters thereof.