Bicyclic modulators of androgen receptor function

A compound according to formula I

• or a pharmaceutically acceptable salt thereof
• wherein
• R1 is selected from hydrogen (H), alkenyl or substituted alkenyl, CO2R4, CONR4R4′ and CH2OR4;
• R2 and R2′ are each independently selected from hydrogen (H), alkyl, substituted alkyl, SR3, halo, NHR4, NHCOR4, NHCO2R4, NHCONR4R4′ and NHSO2R4;
• and at least one of R2 and R2′ is H or alkyl;
• R3 in each functional group is independently selected from hydrogen (H), alkyl or substituted alkyl, CHF2, CF3 and COR4;
• R4 and R4′ in each functional group are each independently selected from hydrogen(H), alkyl or substituted alkyl, alkenyl or substituted alkenyl, alkynyl or substituted alkynyl, cycloalkyl or substituted cycloalkyl, arylalkyl or substituted arylalkyl, and aryl or substituted aryl;
• R5 and R5′ are each independently selected from hydrogen(H), alkyl or substituted alkyl, alkenyl or substituted alkenyl, alkynyl or substituted alkynyl, cycloalkyl or substituted cycloalkyl and arylalkyl or substituted arylalkyl, wherein at least one of R5 and R5′ is hydrogen, or R5 and R5′ taken together can form a double bond with oxygen (O), sulfur (S), NR7 or CR7R7′;
• R6 and R6′ are each independently at each occurrence selected from hydrogen(H), alkyl or substituted alkyl, alkenyl or substituted alkenyl, alkynyl or substituted alkynyl, cycloalkyl or substituted cycloalkyl, and arylalkyl or substituted arylalkyl, wherein at least one of R6 and R6′ is hydrogen, or R6 and R6′ at each occurrence taken together form a double bond with oxygen (O), sulfur (S), or CR7R7′;
• R7 and R7′ in each functional group are each independently selected from hydrogen(H), OR4, alkyl or substituted alkyl, alkenyl or substituted alkenyl, alkynyl or substituted alkynyl, cycloalkyl or substituted cycloalkyl, arylalkyl or substituted arylalkyl, and aryl or substituted aryl;
• G is an aryl group, wherein said group is mono- or polycyclic, and which is optionally substituted with one or more substitutents selected from hydrogen, halo, CN, CF3, OR4, CO2R4, NR4R4′, CONR4R4′, CH2OR4, alkyl or substituted alkyl, alkenyl or substituted alkenyl, alkynyl or substituted alkynyl, cycloalkyl or substituted cycloalkyl, arylalkyl or substituted arylalkyl, and aryl or substituted aryl;
• W is selected from (CR6R6′), C(R6)OR3, or C(R6)(NR4R4′);
• and
• n is 1;
• with the following provisos:
• (a) when R5 and R5′ and/or R6 and R6′ form a double bond with CR7R7′, then when either R7 or R7′ is OR4, R4 is not hydrogen;
• (b) when
• (i) R5 and R5′ are each H or taken together to be =O, =S or =CH2,
• (ii) R6 and R6′ on the imidazolidine portion of the bicyclic structure shown are selected from hydrogen(H), alkyl or substituted alkyl, alkenyl, or substituted alkenyl, alkynyl or substituted alkynyl, cycloalkyl or substituted cycloalkyl, and arylalkyl or substituted aryalkyl, wherein at least one of R6 and R6′ on the imidazolidine portion of the bicyclic structure shown is hydrogen, or R6 and R6′ on the imidazolidine portion of the bicyclic structure shown are taken together to form a double bond with oxygen (O) or sulfur (S),
• (iii) W is CR6R6′ where R6 and R6′ are each independently selected from H, alkyl or substituted alkyl, alkenyl or substituted alkenyl, alkynyl or substituted alkynyl, cycloalkyl or substituted cycloalkyl and arylalkyl or substituted arylalkyl, wherein at least one of R6 and R6′ in W is H, and
• (iv) G has the structure:
• wherein,
• R13 is selected from the group consistng of H, CN, NO2, halo, OR14, CO2R15, CONHR15, COR15, S(O)pR15, SO2NR15R15′, NHCOR15 and NHSO2R15, wherein p is an integer from 0 and 2,
• R14 in each functional group is independently selected from H, alkyl or substituted alkyl, CHF2, CF3 and COR15,
• R15 and R15′ in each functional group are each independently selected from H, alkyl or substituted alkyl, alkenyl or substituted alkenyl, alkynyl or substituted alkynyl, cycloalkyl or substituted cycloalkyl, arylalkyl or substituted arylalkyl, aryl or substituted aryl, heteroaryl or substituted heteroaryl and -CN,
• and
• A and B are each independently selected from H, halo, CN, NO2, alkyl or substituted alkyl and OR14,
• then R2 R2′ are each independently selected from SR3 and NHR4.