Substituted 3-amino-thieno[2,3-b]pyridine-2-carboxylic acid amide compounds and processes for preparing and their uses

A compound of formula (I):

• wherein:
• R1 is
• (a) phenyl or heteroaryl selected from furanyl, thienyl, pyridyl, optionally substituted with one to two R3,
• (b) R6(CH2)mO—,
• (c) R6OCH2—,
• (d) R6(CH2)mNH—,
• (e) R6(CH2)p(CH═CH)m—,
• (f) C1-6alkyl, optionally partially or fully halogenated and optionally substituted with one to two R9,
• (g) C1-8alkoxy, optionally partially of fully halogenated and optionally substituted with one to two R9,
• (h) C1-8alkylthio,
• (i) —N(R4)(R5), or
• (j) —C(O)NHR′, wherein R′ is R6, pyridyl or —CH3,
• R2 is
• (a) heterocyclyl wherein said heterocycle is selected from from 1-piperidinyl, 1-piperazinyl, 4-morpholinyl, 1-pyrrolidinyl, 1,4-diazacycloheptan-1-yl, 1-azepanyl, 2,5-diazabicyclo[2.2.1]heptan-2-yl, oxazepan-4-yl and 4-thiomorpholino and is optionally substituted with one to three R7,
• (b) heterocyclylCH2O— wherein the heterocyclyl is selected from 1-piperidinyl, 1-piperazinyl, 4-morpholinyl and 1-pyrrolidinyl, optionally substituted with C1-6alkyl, or
• C—N(R4)(R5);
• R3 is chosen from C1-6alkyl, C1-6alkoxy, hydroxyC1-6alkyl, halogen, —CN, —CO2H, —CO2C1-6alkyl, —S(O)nC1-6alkyl, —NO2, —OH, —CF3, —N(R4)(R5), —NHC(O)NHC1-6alkyl, —C(O)N(R4)(R5) and phenyl optionally substituted with halogen, C1-6alkyl, —CN or C1-6alkoxy;
• R4 and R5 are independently selected from H, C1-6alkyl, —C(O)C1-6alkyl, pyridyl, benzyl, piperidinyl and phenylethyl;
• R6 is a phenyl group optionally substituted with one or two groups selected from Cl, F, C1-6alkyl, —CN, CO2C1-6alkyl, C(O)NR4R5, —SO2NR2, —NO2, —OH, —NH2, —CF3 and C1-6alkoxy or R6 is C3-6cycloalkyl, —CH2OH, naphthalene-2-yl, naphthalene-1-yl or 2-thienyl;
• R7 is selected from —OH, —CN, oxo, —CO2C1-6alkyl, —C(O)N(R4)(R5), —N(R4)(R5), —CH2N(R4(R5), CH2OH, C1-6alkyl, —C(O)C1-6alkylN(R4)(R5), —NHC(O)N(R4)(R5), —S(O)nC1-6alkyl, H2NCH(R8)C(O)—, HO(CH2)mCH2CH(NH2)C(O)—, HOCH(R6)CH2NH— and —C(O)heterocyclyl, wherein said heterocyclyl is selected from piperidinyl, piperazinyl, morpholinyl and pyrrolidinyl, or R7 is 2-hydroxyethylamino, methylcarbamimidoyl, hydroxyimino, hydrozinocarbonyl, sulfamoyl, methanesulfonylamino, methylsulfonylhydrazino, 2-hydroxypropylamino, 2,3-dihydroxypropylamino, 2-hydroxy-1-methylethylamino, carbamoylmethylamino, N′-phenylhydrazinocarbonyl or toluene-4-sulfonylamino;
• R8 is selected from C1-6alkyl, —(CH2)1-4NH2, phenyl or benzyl;
• R9 is —OH;
• R10 is selected from —OH, —N(R4(R5), C1-6alkoxy and heteroaryl selected from furanyl, thienyl and pyridyl;
• m is 0 or 1;
• n is 0, 1 or 2;
• and
• p is 0, 1, 2 or 3;
• or a pharmaceutically acceptable salt, racemate, racemic mixture, single enantiomer, diastereomeric mixture or an individual diastereomer thereof.