Methods and compositions for treatment of erectile dysfunction

A method for determining an effective dose of a composition comprising one or more erection-producing agents for treating premature ejaculation in a male, the method comprising the steps of:

• a) assessing the general, physical and psychological condition of the male;
• b) administering a test dose guided by step (a);
• c) observing at least one erection characteristic of the male subsequent to administration of the test dose;
• and
• d) adjusting the composition according to the observations in step (d) to provide an effective erection, wherein the composition comprises papaverine, phentolamine, and atropine.

A method of providing treatment of premature ejaculation to a population of male subjects, said method comprising the steps of:

• a) assessing the general, physical and psychological condition of each subject;
• b) formulating a test dose of a pharmaceutical composition of one or more erection-producing agents in an amount effective to cause said subject to sustain an erection, guided by step (a);
• c) administering the test dose;
• d) observing at least one erection characteristic of the subject subsequent to administration of the test dose;
• e) optionally altering the composition according to the observations in step (d) and repeating steps (c) and (d) until an effective erection is obtained, wherein the composition comprises papaverine, phentolamine, and atropine;
• and
• f) prescribing for each said subject a treatment formulated according to steps (a)-(e).

A method of treating sexual dysfunction in a male mammal via ICP administration of a pharmaceutical composition of one or more erection-producing agents in an amount effective to cause said male to sustain an erection, said method comprising the steps of:

• a) assessing the general, physical and psychological condition of the male including assessing a number of factors, said factors including a blood flow, an erection percentage, an incidence of premature ejaculation, an incidence of neurogenic erectile dysfunction, an incidence of psychogenic erectile dysfunction, a quality of sustainability of erection, an incidence of morning erection, a duration of dysfunction, a frequency of penetration, and an age;
• b) formulating a test dose of said composition based on a particular combination of the number of factors by step (a):
• c) administering the test dose;
• d) observing at least one erection characteristic of the male subsequent to administration of the test dose;
• and
• e) adjusting the composition according to the observations in step (d) to provide an effective erection, wherein the composition comprises papaverine, phentolamine, and atropine, wherein the sexual dysfunction is premature ejaculation.