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US 7,405,214 B2Granted
Nucleoside derivatives and therapeutic use thereof
AssigneeRexahn Corporation
InventorsYoung Bok Lee, Chang Ho Ahn, Won Jun Choi, Lak Shin Jeong, Sang Kook Lee
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Abstract
The present invention relates to nucleoside derivatives represented by general formulas I and II, their synthetic methods and their pharmacologically acceptable salts thereof, and compositions containing such compounds. Methods for treating hyperproliferative disorders by administering the compounds are also included.
Claims18
A compound of the formula:
- wherein:
- A is selected from
- Y═H or OH and X═H, F, Cl, Br, I, or CH3;
- or a pharmaceutically acceptable salt thereof with the proviso that, when A is
- X is not CH3.
2 more elements
A method of synthesizing a compound of formula:
- wherein:
- Y═H or OH and X═H, F, Cl, Br, I, or CH3 or a compound of the formula
- wherein:
- Y═H or OH and X═H, F, Cl, Br, or I, comprising at least one step selected from the group:
- wherein B is selected from tert-butyldimethyl silyl, tert-butyldiphenyl silyl, and trityl.
2 more elements
A method for treating a tumor comprising administering a composition comprising a compound of the formula:
- wherein:
- Y═H or OH and X═H, F, Cl, Br, I, or CH3 or a compound of the formula
- wherein:
- Y═H or OH and X═H, F, Cl, Br, or I, or a pharmaceutically acceptable salt thereof to a subject in need of such treatment, and thereby treating the tumor.
1 more element
Dependencies are inferred from the claim text.