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US 7,405,213 B2Granted
Pyrrolotriazine compounds useful as kinase inhibitors and methods of treating kinase-associated conditions therewith
AssigneeBristol-Myers Squibb Company
InventorsPing Chen, Derek J. Norris, Ashvinikumar V. Gavai
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Abstract
The invention relates to at least one pyrrolotriazine derivative, at least one pharmaceutical composition comprising at least one pyrrolotriazine derivative, and at least one method of using at least one pyrrolotriazine derivative to treat at least one kinase associated condition.
Claims21
A compound of Formula (I)
- wherein:
- R1 is
- R2 is H or lower alkyl;
- R3 and R4 are independently H, lower alkyl, substituted lower alkyl, —OR9 or NR10R11;
- n is an integer from 2-6;
- R5 and R6 are independently alkyl, substituted alkyl, or taken together with the N to which they are attached to form a 4 to 7-membered heterocyclic ring or substituted heterocyclic ring optionally containing at least two heteroatoms;
- R7 and R8 are independently H, alkyl or substituted alkyl;
- m is an integer from 0-3;
- L is —OC(═O)NH—, —O—, —C(═O)NH—, —NHC(═O)—, or —NHS (═O)2—;
- R9 is H, alkyl, substituted alkyl, alkylamino, or substituted alkylamino;
- R10 and R11 are independently H, alkyl or substituted alkyl;
- and
- Ar1 is aryl, substituted aryl, heteroaryl, or substituted heteroaryl,
- or a pharmaceutically acceptable salt thereof.
11 more elements
Dependencies are inferred from the claim text.