Antibacterial macrocycles

A compound of the general formula (I)

• in which
• R1 denotes halogen, alkyl, trifluoromethyl, trifluoromethoxy, nitro, amino, alkylamino, dialkylamino or alkylcarbonylamino,
• R2 denotes hydrogen, halogen, alkyl, nitro, amino, alkylamino, dialkylamino, or alkylcarbonylamino,
• R3 denotes hydrogen, halogen, alkyl, nitro, amino, alkylamino, dialkylamino, or alkylcarbonylamino,
• R4 denotes hydrogen, halogen, alkyl, nitro, amino, alkylamino, dialkylamino, or alkylcarbonylamino,
• R5 denotes hydrogen, C1-C4-alkyl, fluorine or chlorine,
• R6 denotes hydrogen, halogen or alkyl,
• R7 and R8a, together with the carbon atom to which R8a is bonded and the nitrogen atom to which R7 is bonded, form a heterocyclyl ring, which optionally can be substituted by 1 or 2 substituents, which independently of one another are selected from the group consisting of halogen, alkyl and amino,
• R8b denotes hydrogen or alkyl,
• R9a denotes hydrogen, alkyl, hydroxyalkyl, carboxylalkyl or aminoalkyl,
• R9b denotes hydrogen or alkyl,
• R10a denotes hydrogen, alkyl or fluorine,
• R10b denotes hydrogen or fluorine,
• R11 denotes hydrogen or alkyl,
• R12 denotes alkyl, alkenyl, cycloalkyl, cycloalkenyl, (cycloalkyl)alkyl, (cycloalkenyl)alkyl, (cycloalkyl)alkenyl (cycloalkenyl)alkenyl,
• where R12 optionally can be substituted by 1, 2 or 3 substituents, which independently of one another are selected from the group consisting of halogen, hydroxyl, alkoxy, fluoroalkoxy, aryloxy, alkanoyloxy, alkoxycarbonyl, aminocarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl, aminosulfonyl, alkylaminosulfonyl, dialkylaminosulfonyl, arylaminosulfonyl, heteroarylaminosulfonyl, heterocyclylaminosulfonyl, aminocarbonylamino, alkoxycarbonylamino,
• or
• R6 and R12, together with the carbon atom to which they are bonded, form a cycloalkyl, which optionally can be substituted by 1 or 2 substituents, which independently of one another are selected from the group consisting of halogen, hydroxyl, alkoxy,
• R13 denotes hydrogen or alkyl,
• A represents a heterocycle which optionally can be substituted by 1, 2 or 3 substituents, which independently of one another are selected from the group consisting of halogen, alkyl, tnfluoromethyl, trifluoromethoxy, nitro, amino, alkylamino, dialkylamino, hydroxyl, alkoxy, alkanoyloxy, carboxyl, alkoxycarbonyl, azido, alkoxycarbonylamino,
• repesents a single or double bond,
• or a pharmaceutically tolerable salt thereof.

A compound of the general formula (I)

• in which
• R1 denotes halogen, alkyl, trifluoromethyl, trifluoromethoxy, nitro, amino, alkylamino, dialkylamino or alkylcarbonylamino,
• R2 denotes hydrogen, halogen, alkyl, nitro, amino, alkylamino, dialkylamino, or alkylcarbonylamino,
• R3 denotes hydrogen, halogen, alkyl, nitro, amino, alkylamino, dialkylamino, or alkylcarbonylamino,
• R4 denotes hydrogen, halogen, alkyl, nitro, amino, alkylamino, dialkylamino, or alkylcarbonylamino,
• R5 denotes hydrogen, C1-C4-alkyl, fluorine or chlorine,
• R6 denotes hydrogen, halogen or alkyl,
• R7 denotes alkyl or (cycloalkyl)alkyl,
• R8a denotes alkyl, alkylene, cycloalkyl or (cycloalkyl)alkyl,
• where R8a optionally can be substituted by 1, 2 or 3 substituents, which independently of one another are selected from the group consisting of hydroxyl, alkoxy, a radical —OR8a-1, carboxyl, alkoxycarbonyl, amino, alkylamino, dialkylamino, aminocarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl, aminosulfonyl, alkylaminosulfonyl, dialkylaminosulfonyl, arylaminosulfonyl, heterocyclylaminosulfonyl, heteroarylaminosulfonyl, aminocarbonylamino, hydroxycarbonylamino, alkoxycarbonylamino, aminocarbonyloxy, in which R8a-1 is a carbonyl-bonded amino acid radical,
• or R7 and R8a, together with the carbon atom to which R8a is bonded and the nitrogen atom to which R7 is bonded, form a heterocyclyl ring, which optionally can be substituted by 1, 2 or 3 substituents, which independently of one another are selected from the group consisting of halogen, alkyl, trifluoromethyl, trifluoromethoxy, nitro, azido, amino, alkylamino, dialkylamino, hydroxyl, alkoxy, alkanoyloxy,
• R8b denotes hydrogen or alkyl,
• R9a denotes hydrogen, alkyl, hydroxyalkyl, carboxylalkyl or aminoalkyl,
• R9b denotes hydrogen or alkyl,
• R10a denotes hydrogen, alkyl or fluorine,
• R10b denotes hydrogen or fluorine,
• R11 denotes hydrogen or alkyl,
• R12 denotes C3-C8-alkyl,
• R13 denotes hydrogen or alkyl,
• A represents a heterocycle which optionally can be substituted by 1, 2 or 3 substituents, which independently of one another are selected from the group consisting of halogen, alkyl, trifluoromethyl, trifluoromethoxy, nitro, amino, alkylamino, dialkylamino, hydroxyl, alkoxy, alkanoyloxy, carboxyl, alkoxycarbonyl, azido, alkoxycarbonylamino,
• represents a single or double bond,
• or a pharmaceutically tolerable salt thereof.