Generation and use of dendritic cells
AssigneeUniversite Libre de Bruxelles
InventorsMichel Goldman, Emmanuel Bartholomé, Christel Buelens, Fabienne Willems
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Abstract
The present invention relates to an in vitro method for differentiation and maturation of isolated monocytes into IL3-R+CD11c+ myeloid dendritic cells consisting of incubating the monocytes with a combination of a type I interferon and IL-3.
Claims10
A method for differentiation and maturation of isolated monocytes into stimulated IL3-R+CD11c+ myeloid dendritic cells consisting of (a) incubating said monocytes with a combination of IFN-β and IL-3 and (b) incubating the IL3-R+CD11c+ myeloid dendritic cells with a stimulant chosen from a group consisting of virus, bacterium, lipopolysaccharide (LPS), nucleic acid, and a combination thereof.
A method for differentiation and maturation of isolated monocytes into stimulated IL3-R+CD11c+ myeloid dendritic cells consisting of (a) incubating said monocytes with a combination of IFN-β and IL-3 and (b) incubating the IL3-R+CD11c+ myeloid dendritic cells with poly (I:C).
Dependencies are inferred from the claim text.