Lipid nanoparticle based compositions and methods for the delivery of biologically active molecules
AssigneeSirna Therapeutics, Inc.
InventorsTongqian Chen, Chandra Vargeese, Kurt Vagle, Weimin Wang, Ye Zhang
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Abstract
The present invention relates to novel cationic lipids, transfection agents, microparticles, nanoparticles, and short interfering nucleic acid (siNA) molecules. Specifically, the invention relates to novel cationic lipids, microparticles, nanoparticles and transfection agents that effectively transfect or deliver short interfering nucleic acid (siNA). The compositions described herein are generally referred to as formulated molecular compositions (FMC) or lipid nanoparticles (LNP).
Claims10
A lipid nanoparticle (LNP) composition comprising one or more short interfering nucleic acid (siNA) molecules, 3-Dimethylamino-2-(Cholest-5-en-3β-oxybutan-4-oxy)-1-(cis,cis-9,12-octadecadienoxy) propane (CLinDMA), distearoylphosphatidylcholine (DSPC), Cholesterol, and 1-[8′-(1,2-Dimyristoyl-3-propanoxy)-carboxamido-3′,6′-dioxaoctanyl]carbamoyl-ω-methyl-poly(ethylene glycol) (PEG-DMG).
Dependencies are inferred from the claim text.