US 7,404,961 B2 · Peptides responsive to antibodies against consensus peptide of the CS4-CFA/I family proteins

Abstract

This invention relates to amino acid sequences from within a consensus peptide of the formula: VEKNITVTASVDPTIDLLQADGSALPSAVALTYSPA (SEQ ID. NO: 1) Eight mer peptides from within the consensus peptide were tested against an antibody raised to the consensus peptide. Studies relating to antibody raised to denatured proteins from the natural organisms producing the family of proteins were also useful and showed particular value of some sequences. A sequence of the formula ASVDPTIDLLQA (SEQ ID NO: 2) was identified thereby. An enlarge sequence of the formula TVTASVDPTIDLLQAD (SEQ ID NO: 3) is also especially interesting as are intermediate sequences such as sequences VTASVDPTIDLLQAD (SEQ ID NO: 4), TASVDPTIDLLQAD (SEQ ID NO: 5), and TASVDPTIDLLQA (SEQ ID NO: 6) as being binding sites for antibodies raised to the denatured proteins.

Claims13

Dependent claims

An isolated peptide selected from the group consisting of SEQ ID NO:

2, SEQ ID NO:
3, SEQ ID NO:
4, SEQ ID NO:
5, SEQ ID NO:
6, SEQ ID NO:
7, SEQ ID NO:
8, SEQ ID NO:
11, SEQ ID NO:
13, SEQ ID NO:
14, SEQ ID NO:
15, SEQ ID NO:
16, SEQ ID NO:
17, SEQ ID NO:
18, SEQ ID NO:
19, SEQ ID NO:
20, SEQ ID NO:
21, SEQ ID NO:
22, SEQ ID NO:
23, SEQ ID NO:
24, SEQ ID NQ:
26, SEQ ID NO:
27, SEQ ID NO:
28, SEQ ID NO:
29, SEQ ID NO:
30, SEQ ID NO:
31, SEQ ID NO:
32, SEQ ID NO:
33, and SEQ ID NO:
35.

26 more elements

Dependencies are inferred from the claim text.

Facts

Application

10/754,642Filed 12 Jan 2004 · continuation in part

Priority

2 Aug 1996

Published

US 2004/0229772 A118 Nov 2004

Granted

29 Jul 2008

Term ends

Not estimatedThe source records don’t support an estimate.

Classification11 codes

C07K 16/1232
Enterobacterales , e.g. Citrobacter , Serratia , Proteus , Providencia , Morganella or Yersinia: escherichia
C07K 14/245
From Enterobacteriaceae , e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia: escherichia
C12N 1/00
Microorganisms
A61K 38/00
Medicinal preparations containing peptides

Family

Application60/023,076Us provisional application · filed 2 Aug 1996

Application08/905,140Parent of this continuation · filed 1 Aug 1997

Application09/801,784Parent of this continuation-in-part · filed 9 Mar 2001

US 2004/0229772 A1Pre-grant publication · published 18 Nov 2004

Application09/801,784Parent of this continuation

US 2001/0014668 A1Published application

US 7,404,961 B2This patent

From the US filing history. Foreign family members aren’t listed.

Peptides responsive to antibodies against consensus peptide of the CS4-CFA/I family proteins

Life of this patent

Peptides responsive to antibodies against consensus peptide of the CS4-CFA/I family proteins

Life of this patent

Abstract

Claims13