Multivalent vaccine composition having increased stability of capsular polysaccharide
AssigneeAventis Pasteur Limited
InventorAlain Françon
Life of this patent
Estimating the term…
Abstract
A vaccine composition comprising two valences is provided: (i) a first valence which is adjuvant-enhanced with aluminum hydroxide and (ii) a second valence which contains a polysaccharide of bacterial capsule comprising one or more o-acetyl groups and which is not adsorbed with aluminum oxide due to the presence of a protecting compound which may be a phosphate, a citrate or a carbonate and which prevents the adsorption. The first valence can be any vaccine valence. In one particular embodiment, the vaccine composition contains (i) Hepatitis A valence, adsorbed on aluminum hydroxide and (ii) the typhoid fever valence formed by the polysaccharide Vi of the Salmonella typhi capsule.
Claims10
An immunization composition comprising (i) a first valence adjuvanted with an aluminum compound comprising hydroxide groups, (ii) a second valence comprising a bacterial capsule polysaccharide comprising one or more O-acetyl groups, and (iii) phosphate, citrate, and/or carbonate ions in an amount sufficient to prevent adsorption of the second valence onto the aluminum compound, wherein the first valence is hepatitis A valence and the second valence is a typhoid fever Salmonella typhi capsular Vi polvsaccharide.
Dependencies are inferred from the claim text.