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AssigneeThe Regents of the University of California
InventorsKeith E. Mostov, Steven J. Chapin, Janice Richman-Eisenstat
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The invention provides compositions and methods for specific binding to a region of the polymeric immunoglobulin receptor (pIgR) of a cell with the provisos that the ligand does not substantially bind to the most abundant form of the secretory component (SC) of pIgR present in an organ of interest of an animal of interest under physiological conditions, and does not bind to the pIgR stalk. In some embodiments, the ligand decreases cleavage of SC from the stalk by at least one-third. The ligands and methods of the invention can be used with both birds and mammals. In more preferred embodiments, the animal is a mammal. In the most preferred embodiment, the animal is a human. The ligand may be targeted into the cell or may undergo retrograde transcytosis and release at the basolateral side of the cell, and may comprise a biologically active composition.
A method of targeting an effector moiety to an epithelial cell of an organ of interest in an animal, which cell has an apical surface and expresses a polymeric immunoglobulin receptor (pIgR), which pIgR when cleaved has a stalk region which remains attached to the cell and a secretory component which exists in the organ of interest in several forms, by contacting pIgR attached to said apical surface with an immunoconjugate comprising an effector moiety and an antibody, which antibody binds pIgR, with the provisos that
Dependencies are inferred from the claim text.