Peptidic conjugates for alopecia prevention and treatment

A peptide corresponding to the formula (I)

• W-Lys-Asp-Val-Z (I) (SEQ ID NO. 1-2)
• or its peptide conjugate corresponding to the formula (II)
• A-W-Lys-Asp-Val-Z (II) (SEQ ID NO. 3-4)
• in which A represents the radical corresponding to a monocarboxylic acid of general formula (III)
• HOOC—R (III)
• in which R represents a C1-C24 aliphatic radical, linear or branched, possibly substituted by a hydroxy group, capable of including one or more unsaturations, lipoic acid or its reduced form, dihydrolipoic acid, N-lipoyl-lysine, or retinoic acid, and
• W represents Glu-Gln-Arg, Arg-Lys, Arg-Lys-Asp, Arg or a bond,
• when Z represents Tyr-Val-Gln-Leu-Tyr-NH2 (SEQ ID NO:12), Leu-DOPA, DOPA-NH2, or HomoPhe-NH2,
• or
• W represents Gly-Gln-Gln or Glu-Gln, when Z represents Tyr-Val-Gln-Leu-Tyr-NH2 (SEQ ID NO:12), Leu-DOPA, Val-Tyr-OH, Val-Tyr-NH2, Tyr-NH2, Tyr-OH, DOPA-NH2, or HomoPhe-NH2, in the form of enantiomers or diastereomers, as well as their mixtures, including racemic mixtures, the peptide of formula (I) and the peptide conjugate of formula (II) which can be present in the form of complexes with zinc.