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US 7,402,730 B1Granted
Knockout animals manifesting hyperlipidemia
AssigneeLexicon Pharmaceuticals, Inc.
InventorsMary Jean Sparks, Wenhu Huang
Life of this patent
Estimating the term…
Abstract
Genetically engineered cells and animals are described that incorporate a mutated GHP1 allele. Animals that are homozygous for the mutated GHP1 allele are useful for the production of monoclonal antibodies against GHP1.
Claims2
A transgenic mouse whose genome comprises a disruption of the GPI-anchored HDL Binding protein 1 (GHP1) gene, wherein said mouse exhibits an increase in serum cholesterol levels when compared to a control mouse.
Dependencies are inferred from the claim text.