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US 7,402,728 B2Granted
Transgenic mice expressing human CD20 and/or CD16
AssigneeGenentech, Inc.
InventorsAndrew Chee-Yuen Chan, Qian Gong, Flavius Martin
Life of this patent
Estimating the term…
Abstract
The present invention generally relates to non-human transgenic animals expressing human cellular markers, including CD20 and/or preferably CD16.
Claims23
A transgenic mouse whose genome comprises a first nucleotide sequence encoding human CD20 and a second nucleotide sequence encoding a subunit of a heterologous FcγIII receptor (CD16), wherein the first nucleotide sequence is operably linked to a CD20 promoter, and wherein the second nucleotide sequence is operably linked to a FcγIII receptor promoter.
Dependencies are inferred from the claim text.