Non-human animal exhibiting bone metastasis of tumor cells
AssigneeChugai Seiyaku Kabushiki Kaisha
InventorsSaburo Sone, Toyokazu Miki
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Abstract
The present invention provides a non-human bone metastasis model animal in which tumor cells capable of inducing bone metastasis by peripheral administration have been introduced, and a method for producing the animal. The bone metastasis model animal in the present invention may be useful for understanding the biology of bone metastasis and developing novel therapeutic strategies for lung cancer patient with multi-organ metastases, including bone metastasis.
Claims13
A bone metastasis model mouse exhibiting bone metastasis of tumor cells, wherein a suspension comprising single cells of human small cell lung carcinoma SBC-5 cells has been introduced by intravenous administration, wherein the mouse is immunodeficient, and wherein the metastasis occurs in the mouse's own bone.
A method for producing a mouse exhibiting bone metastasis of tumor cells, comprising:
- (i) providing an immunodeficient mouse;
- and
- (ii) introducing a suspension comprising single cells of human small cell lung carcinoma SBC-5 cells into the mouse by intravenous administration, wherein the metastasis occurs in the mouse's own bone.
Dependencies are inferred from the claim text.