Methods and compositions for screening for modulators of Parkinson's disease
AssigneeUniversity of Washington
InventorsLeo J. Pallanck, Jessica G. Zuniga, Alexander J. Whitworth
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Abstract
Methods and compositions for identifying an agent (e.g., a gene product or small molecule compound) that modulates a Parkinson's disease phenotype are provided. In practicing the subject methods, a non-mammalian animal model, such as Drosophila melanogaster, that includes a mutant parkin gene and at least one other mutant gene are evaluated for a Parkinson's disease phenotype. Also provided are kits, and systems for practicing the subject methods, as well as methods of use of agents identified in the screening method of the invention.
Claims5
A Drosophila melanogaster model for Parkinson's disease comprising a non-functional mutant parkin gene and a non-functional mutant of at least one non-parkin gene selected from the group consisting of GstS1, GstE1, CG2789, CG12505, CG16820 and Dgp-1.
Dependencies are inferred from the claim text.