Longevity and PAPP-A
AssigneeMayo Foundation for Medical Education and Research
InventorCheryl A. Conover
Life of this patent
Estimating the term…
Abstract
This document provides materials and methods related to PAPP-A polypeptides, aging, and transgenic non-human mammals whose genomes comprise a disrupted PAPP-A allele. Methods for making such transgenic non-human mammals, and using them and other mammals to identify and characterize agents that affect conditions related to PAPP-A activity, such as vascular restenosis, atherosclerosis, wound healing, cancer, fibrosis, bone development, fetal development, longevity, and fracture repair, also are provided.
Claims7
A method for identifying a compound having the ability to increase the average lifespan of a population of mice, said method comprising:
- (a) administering a test compound having the ability to reduce PAPP-A polypeptide activity to a population of mammals, and
- (b) determining whether or not said population has a longer average lifespan than the average lifespan of a control population not administered said test compound, wherein the presence of said longer average lifespan indicates that said test compound is said compound having the potential ability to increase the average lifespan of said population of mice.
Dependencies are inferred from the claim text.