Loading patent…
AssigneeMitsui Chemicals, Inc.
InventorsKazuya Matsumoto, Yasushi Kazuno, Norikazu Higashimura, Toshihisa Ohshima, Haruhiko Sakuraba
Estimating the term…
An industrial process for producing hydroxyaldehydes efficiently, by solving the problems of conventional DERA, such as low stability against aldehydes, low catalytic activity for aldol condensation, and the difficulty of controlling the number of acetaldehyde molecules to be condensed, is provided. According to the process, aldol condensation of a substituted or unsubstituted aliphatic aldehyde compound having 2 to 6 carbon atoms with acetaldehyde is conducted by using D-2-deoxyribose-5-phosphate aldolase which is highly stable against aldehydes and has high catalytic activity for aldol condensation, whereby a hydroxyaldehyde compound having the number of carbon atoms increased by two or four can be produced.
A process for producing a hydroxyaldehyde compound, comprising conducting aldol condensation of a substituted or unsubstituted aliphatic aldehyde compound having 2 to 6 carbon atoms with a single molecule of acetaldehyde to produce a hydroxyaldehyde compound having the number of carbon atoms increased by two, using a D-2-deoxyribose-5-phosphate aldolase having a property of retaining 50% or greater of activity after treating at 25° C. for 30 minutes in an aqueous medium containing 100 mM of chioroacetaldehyde, wherein the D-2-deoxvribose-5-phosphate aldolase comprises SEQ ID NO:
A process for producing a compound represented by General Formula (7), comprising conducting aldol condensation of a compound represented by General Formula (1) with two molecules of acetaldehyde to produce a compound represented by General Formula (7), having the number of carbon atoms increased by four, using D-2-deoxvribose-5-phosphate aldolase having a property of retaining 50% or greater of activity after treating at 25° C. for 30 minutes in an aqueous medium containing 100 mM of chloroacetaldehyde, wherein the D-2-deoxyribose-5-phosphate aldolase comprises SEQ ID NO:
Dependencies are inferred from the claim text.