Polyisoprenylated benzophenones and their isomers as inhibitors of histone acetyltransferases and uses thereof

A process for preparation of derivatives of compound Garcinol and Isogarcinol of formula I and II, respectively, said process comprising steps of reacting Garcinol or Isogarcinol with halo compounds to obtain the derivatives with the selected substituents of R1, R2, R3, R4 and R5, at temperature ranging between 30-40° C. under alkaline conditions in presence of organic solvents, and purifying the derivatives.

A method of inhibiting histone acetyltransferase (HAT) in a subject, wherein said method comprises a step of administering a derivative of Garcinol or Isogarcinol of formula I or formula II

• respectively, to the subject, wherein R1, R2, and R3, substituents of the Garcinol derivative of formula I, and R4 and R5, substituents of the Isogarcinol derivative of formula II, are selected from the group consisting of methoxy, ethoxy, isopropoxy, allyloxy, butoxy, t-butoxy, pentoxy, hexyloxy, O—CH2—COOh, O—CO—CH2Cl, O—SO2—CH3, and O—CH2—CHOH—CH3.