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US 7,402,686 B2Granted
Cannabinoid crystalline derivatives and process of cannabinoid purification
AssigneeMallinckrodt Inc.
InventorJohn Robert Duchek
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Abstract
Δ9 tetrahydrocannabinol (THC) esters comprising the reaction product of THC with at least one aryl sulfonyl chloride in the presence of at least one tertiary amine. The resulting aryl sulfonic THC esters are highly crystalline and stable at room temperature in air, allowing for indefinite storage. The aryl sulfonic THC esters can be recrystallized for purification, and then hydrolyzed to recover the purified THC.
Claims15
A process for the preparation of cannabinoid aryl sulfonates comprising:
- reacting at least one cannabinoid with at least one aryl sulfonyl halide in the presence of at least one base R5R6R7N, wherein R5, R6 and R7 are lower alkyls of 1 to about 6 carbon atoms, and a solvent, wherein the cannabinoid aryl sulfonates are crystalline and stable at room temperature under air.
A process for the purification of a cannabinoid comprising:
- esterifying the cannabinoid with at least one aryl sulfonyl halide in the presence of at least one base R5R6R7 N, wherein R5, R6and R7 are lower alkyls of 1 to about 6 carbon atoms, to form a cannabinoid aryl sulfonate;
- and
- allowing the cannabinoid aryl sulfonate to crystallize, wherein the cannabinoid aryl sulfonate is crystalline and stable at room temperature under air.
A process for the purification of a cannabinoid comprising:
- esterifying the cannabinoid with at least one aryl sulfonyl halide in the presence of at least one base R5R6R7N, wherein R5, R6 and R7 are lower alkyls of 1 to about 6 carbon atoms, to form a cannabiniod aryl sulfonate;
- allowing the cannabinoid aryl sulfonate to crystallize;
- and,
- hydrolyzing the cannabinoid aryl sulfonate to recover the cannabinoid, wherein the cannabinoid aryl sulfonate is crystalline and stable at room temperature under air.
1 more element
Dependencies are inferred from the claim text.