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US 7,402,683 B2Granted
Cinnamic acid amides
AssigneeBayer HealthCare LLC
InventorsNina Brunner, Christoph Freiberg, Thomas Lampe, Ben Newton, Michael Otteneder, Josef Pernerstorfer, Jens Pohlmann, Guido Schiffer, Mitsuyuki Shimada, Niels Svenstrup, Rainer Endermann, Peter Nell
Life of this patent
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Abstract
The present invention relates to compounds, to processes for preparing them, to pharmaceutical compositions comprising them, and to their use in the therapy and/or prophylaxis in illnesses in people or animals, especially diseases of bacterial infection.
Claims17
A compound of the formula
- in which
- R1 is hydrogen, methyl or halogen,
- R1′ is hydrogen, methyl or halogen,
- R2 hydrogen is or methyl,
- R3 is hydrogen, hydroxyl, amino, C1-C3 alkyl, C1-C3 alkoxy, benzyloxy, C1-C3 alkylamino, C1-C3 alkylcarbonylamino, phenylcarbonylamino or benzylcarbonylamino,
- R4 is hydrogen or C1-C3 alkyl,
- R5 is halogen, trifluoromethyl, trifluoromethoxy, nitro, amino, alkylamino, hydroxyl, alkyl, alkoxy, carboxyl, alkoxycarbonyl, benzyloxycarbonyl, aminocarbonyl, alkylaminocarbonyl, aryl or heteroaryl,
- or
- two substituents R5 together with the carbon atoms to which they are attached form a dioxolane ring fused to the A ring, which may be substituted by 0, 1 or 2 substituents R5-1, the substituents R5-1 being selected independently of one another from the group consisting of halogen, nitro, amino, trifluoromethyl, hydroxyl and alkoxy,
- R6 is alkyl, cycloalkyl or cycloalkenyl,
- it being possible for R6 to be substituted by 0, 1, 2 or 3 substituents R6-1, the substituents R6-1 being selected independently of one another from the group consisting of halogen, nitro, amino, trifluoromethyl, hydroxyl, alkyl and alkoxy,
- n is a number 0, 1, 2 or 3,
- it being possible for the radicals R5 to be identical or different when n is 2 or 3,
- m is a number 1, 2 or 3,
- A is aryl or heteroaryl,
- it being possible for A to be substituted by 0, 1, 2 or 3 substituents RA, the substituents RA being selected independently of one another from the group consisting of halogen, alkyl, nitro, amino, cyano, trifluoromethyl, aryl, heteroaryl, hydroxyl, alkoxy, alkylamino, carboxyl, alkoxycarbonyl, aminocarbonyl, alkylcarbonylamino and alkylaminocarbonyl,
- or
- two substituents RA together with the carbon atoms to which they are attached form a dioxolane ring fused to the A ring, which may be substituted by 0, 1 or 2 substituents RA-1, the substituents RA-1 being selected independently of one another from the group consisting of halogen, nitro, amino, trifluoromethyl, hydroxyl and alkoxy,
- B is aryl or heteroaryl,
- or a pharmaceutically acceptable salt, solvate or hydrate thereof.
17 more elements
Dependencies are inferred from the claim text.