Modified peptide
AssigneeUniversity of Ulster
InventorsPeter Raymond Flatt, Finbarr Paul Mary O'Harte
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Abstract
The invention provides a peptide based on biologically active CCK-8 having improved characteristics for the treatment of obesity and/or type 2 diabetes wherein the primary structure of CCK-8 is: Asp1Tyr2(SO3H)-Met3Gly4Trp5Met6Asp7Phe8amide (SEQ ID NO:1) and wherein the peptide has at least one amino add substitution and/or modification and is not Asp1-glucitol CCK-8. The invention also provides the use of the peptide in the preparation of a medicament to inhibit food intake, induce satiety, stimulate insulin secretion, moderate blood glucose excursions, enhance glucose disposal and/or exhibit enhanced stability in plasma compared to native CCK-8 and/or for treatment of obesity and/or type 2 diabetes.
Claims4
An isolated peptide based on biologically active cholecystokinin-8 (CCK-8) (SEQ ID NO:
- 1), wherein said peptide is SEQ ID NO:
- 1, wherein pGlu-Gln is attached to the N-terminal Asp.
Dependencies are inferred from the claim text.