Thymic stromal lymphopoietin receptor molecules and uses thereof
AssigneesWhitehead Institute for Biomedical Research, The Government of the United States of America, Health Research, Inc. (Roswell Park Division), University of Washington
InventorsAkhilesh Pandey, Katsutoshi Ozaki, Heinz Baumann, Steven D. Levin, Andrew G. Farr, Warren J. Leonard, Harvey F. Lodish
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Abstract
The present invention provides Thymic Stromal Lymphopoietin Receptor (TSLPR) polypeptides and nucleic acid molecules encoding the same. The invention also provides selective binding agents, vectors, host cells, and methods for producing TSLPR polypeptides. The invention further provides pharmaceutical compositions and methods for the diagnosis, treatment, amelioration, and/or prevention of diseases, disorders, and conditions associated with TSLPR polypeptides.
Claims19
A polypeptide produced by a process comprising culturing an isolated host cell comprising a vector comprising a nucleic acid molecule under suitable conditions to express the polypeptide, and optionally isolating the polypeptide from the culture, wherein the nucleic acid molecule is selected from the group consisting of:
- (a) the nucleotide sequence as set forth in SEQ ID NO:
- 1;
- (b) a nucleotide sequence encoding the polypeptide as set forth in SEQ ID NO:
- 2;
- and
- (c) a nucleotide sequence that hybridizes to the complement of the nucleotide sequence of either (a) or (b) at
- (i) 65-68° C. in a hybridization buffer comprising 0.015 M sodium chloride and 0.0015 M sodium citrate or
- (ii) 42° C. in a hybridization buffer comprising 0.015 M sodium chloride, 0.0015 M sodium citrate, and 50% formamide,
- and encodes a polypeptide that binds thymic stromal lymphopoietin and is at least 97% identical to SEQ ID NO:
- 2.
An isolated polypeptide comprising the amino acid sequence encoded by SEQ ID NO:
- 1.
An isolated polypeptide comprising the amino acid sequence as set forth in SEQ ID NO:
- 2.
An isolated polypeptide comprising (a) the amino acid sequence as set forth in SEQ ID NO:
- 3, optionally further comprising an amino-terminal methionine;
- or (b) a amino acid sequence which is at least 97 percent identical to the amino acid sequence of SEQ ID NO:
- 2, wherein the polypeptide binds thymic stromal lymphopoietin.
Dependencies are inferred from the claim text.