Olopatadine formulations for topical administration
AssigneeAlcon Inc.
InventorsErnesto J. Castillo, Wesley Wehsin Han, Huixiang Zhang, Haresh G. Bhagat, Onkar N. Singh, Joseph Paul Bullock, Suresh C. Dixit
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Abstract
Topical formulations of olopatadine for treatment of allergic or inflammatory disorders of the eye and nose are disclosed. The aqueous formulations contain approximately 0.17-0.62% (w/v) of olopatadine and an amount of polyvinylpyrrolidone or polystyrene sulfonic acid sufficient to enhance the physical stability of the formulations.
Claims1
A topically administrable solution composition for treating allergic or inflammatory disorders of the eye and nose, wherein the solution has a pH from 6.5-7.5 and a viscosity of 1-2 cps, and wherein the solution consists essentially of:
- a) 0.18-0.22% (w/v) olopatadine;
- b) 1.5-2% (w/v) polyvinylpyrrolidone having a weight average molecular weight of 50,000-60,000;
- c) a preservative selected from the group consisting of benzalkonium chloride;
- benzododecinum bromide;
- and polyquaternium-1;
- d) edetate disodium;
- e) a tonicity-adjusting agent selected from the group consisting of mannitol and sodium chloride;
- f) a buffering agent selected from the group consisting of phosphates and borates;
- g) optionally a pH-adjusting agent selected from the group consisting of NaOH and HCl;
- and
- h) water.
Dependencies are inferred from the claim text.