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US 7,402,602 B2Granted
Imidazole derivatives modulating the sodium channels
AssigneeSociete de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S.)
InventorsDennis Bigg, Jacques Pommier, Anne-Marie Liberatore
Life of this patent
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Abstract
A method of treating cardiac rhythm disorders linked with neurodegenerating depression, bipolar disorders and irritable bowel disorders in warm-blooded animals in need thereof by administering a compound of the formula wherein the substituents are defined as in the specification.
Claims3
A method of treating depression, bipolar disorder, and irritable bowel syndrome in warm blooded animals comprising administering to warm-blooded animals in need thereof an amount of a compound of the formula
- wherein
- R1 is alkyl of 3 to 16 carbon atoms or a cycloalkylalkyl, the cycloalkyl of which contains 3 to 7 carbon atoms and the alkyl of which is 1 to 6 carbon atoms,
- or R1 is aralkyl optionally substituted 1 to 3 times on the aryl with at least one member selected from the group consisting of halogen, alkyl and alkoxy of 1 to 6 carbon atoms;
- R2 is phenyl optionally substituted 1 to 3 times by at least one member selected from the group consisting of halogen, alkyl and alkoxy of 1 to 6 carbon atoms,
- or R2 is biphenyl optionally substituted 1 to 4 times by at least one member of the group consisting of halogen, and alkyl and alkoxy of 1 to 6 carbon atoms;
- R3 is hydrogen or alkyl of 1 to 6 carbon atoms;
- and its pharmaceutically acceptable salts.
4 more elements
Dependencies are inferred from the claim text.