Arylethanolamine β2-adrenoreceptor agonist compounds

A compound of formula (I)

• or a salt thereof, wherein:
• n is an integer of from 2 to 8;
• m is an integer of from 3 to 11, with the proviso that the sum of n+m is from 5 to 19;
• R1 is —XSO2NR6R7;
• wherein X is —(CH2)p- or C2-6 alkenylene;
• p is an integer from 0 to 6;
• R6 and R7 are independently selected from hydrogen, C1-6alkyl, C3-7cycloalkyl, CONR8R9, phenyl and phenyl(C1-4alkyl)-,
• or R6 and R7, together with the nitrogen atom to which they are bonded, form a 5-, 6- or 7- membered nitrogen containing ring;
• and R6 and R7 are each independently optionally substituted by 1 or 2 groups independently selected from halo, C1-6alkyl, C1-6alkoxy, hydroxy-substituted C1-6alkoxy,
• C1-6haloalkyl, CO2R8, SO2R8R9, —CONR8R9, —NR8C(O)R9 or a 5-, 6- or 7-membered heterocyclic ring;
• R8 and R9 are independently selected from hydrogen, C1-6alkyl, C3-7cycloalkyl, phenyl and phenyl(C1-6alkyl)-;
• R2 and R3 are independently selected from hydrogen, C1-6alkyl, C1-6alkoxy, halo, phenyl and C1-6haloalkyl;
• R4 and R5 are independently selected from hydrogen and C1-4 alkyl with the proviso that the total number of carbon atoms in R4 and R5 is not more than 4, and
• Ar is a group selected from the group consisting of:
• wherein R11 represents hydrogen, halogen, —(CH2)qOR14, —NR14C(O)R15, —NR14SO2R15,
• —SO2NR14R15, —NR14R15, —OC(O)R16 or OC(O)NR14R15, and R10 represents hydrogen, halogen or C1-4 alkyl;
• or R11 represents —NHR17 and R10 and —NHR17 together form a 5- or 6-membered heterocyclic ring;
• R12 represents hydrogen, halogen, —OR14 or —NR14R15;—OC(O)R16 or —OC(O)NR14R15;
• R13 represents hydrogen, halogen, haloC1-4 alkyl, —OR14 or —NR14 R15;
• R14 and R15 each independently represents hydrogen or C1-4 alkyl, or in the groups
• —NR14R15, —SO2NR14R15 and —OC(O)NR14R15, R14 and R15 independently represent hydrogen or C1-4 alkyl or together with the nitrogen atom to which they are attached form a 5-, 6- or 7-membered nitrogen-containing ring,
• R16 represents an aryl group which may be unsubstituted or substituted by one or more substituents selected from halogen, C1-4 alkyl, hydroxy, C1-4 alkoxy or halo C1-4 alkyl;
• and
• q is zero or an integer from 1 to 4;
• provided that Ar is not a group (a) wherein R11 is (CH2)qOR14 or NR14COR15, and R12 is OR14.