Sulfated bis-cyclic agents
AssigneeVirginia Commonwealth University
InventorsUmesh R. Desai, Gunnar Gunnarsson
Life of this patent
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Abstract
Sulfated bis-cyclic compounds that are potent anticoagulants and methods for their manufacture are provided. The sulfated compounds are bis-cyclic moieties comprised of an isoquinoline ring joined to a phenyl ring with the general chemical structure formula (I) where R2 is hydrogen or a sulfate moiety, R3 is either hydrogen or carboxylate moiety; R4 is a hydrogen or oxygen; and R5 is a hydrogen if R4 is a hydrogen, and is absent if R4 is oxygen. Counterions such as sodium may also be coordinated to the sulfate and carboxylate moieties.
Claims15
A sulfated compound having the chemical structure:
- wherein
- R2 is selected from the group consisting of hydrogen and sulfate moieties, and may be the same or different at each location, provided that at least one location is a sulfate moiety, and
- R3 is selected from the group consisting of hydrogen and a carboxylate moiety,
- R4 is a hydrogen or oxygen, and
- R5 is a hydrogen if R4 is a hydrogen, and is absent if R4 is oxygen.
An anticoagulation method comprising the step of exposing blood or a component thereof to a compound having the chemical structure:
- wherein
- R2 is selected from the group consisting of hydrogen and sulfate moieties, and may be the same or different at each location, provided that at least one location is a sulfate moiety, and
- R3 is selected from the group consisting of hydrogen and a carboxylate moiety,
- R4 is a hydrogen or oxygen, and
- R5 is a hydrogen if R4 is a hydrogen, and is absent if R4 is oxygen.
Dependencies are inferred from the claim text.