Monohydrated sodium salt of S-tenatoprazole and the use thereof in therapy
AssigneeSidem Pharma
InventorsAvraham Cohen, François Schutze, Suzy Charbit, Frédéric Martinet, Hervé Ficheux, Michel Homerin
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Abstract
The present invention relates to S-tenatoprazole monohydrated sodium salt, represented by the following formula and the use thereof in therapy for the treatment of digestive diseases.
Claims18
The monohydrated sodium salt of S-tenatoprazole represented by the general formula (II):
A method for the treatment of digestive diseases comprising administering to a subject in need thereof a therapeutically effective amount of the monohydrated sodium salt of S-tenatoprazole substantially free from the (+) enantiomer or R-tenatoprazole wherein digestive diseases are selected from gastro-oesophageal reflux disease and digestive bleeding in polymedicamented patients.
An enantioselective method of preparation of the monohydrated sodium salt of S-tenatoprazole, wherein an enantioselective oxidation is conducted on a sulphide of the following general formulation (I)
- A-CH2—S—B (I)
- where A is a 4-methoxy-3,5-dimethyl-2-pyridyl group and B represents a 5-methoxy-imidazo[4, 5-b]pyridyl group,
- using an oxidising agent in the presence of a vanadium based catalyst and a chiral ligand in a specific sulphide solvent and a specific ligand solvent, followed by salification by sodium hydroxide, in order to obtain the monohydrated sodium salt of S-tenatoprazole.
Dependencies are inferred from the claim text.