US 7,402,592 B2 · Pharmaceutical compositions and methods for relieving pain and treating central nervous system disorders

Abstract

Patients susceptible to or suffering from disorders, such as central nervous system disorders, which are characterized by an alteration in normal neurotransmitter release, such as dopamine release (e.g., Parkinsonism, Parkinson's Disease, Tourette's Syndrome, attention deficient disorder, or schizophrenia), are treated by administering a compound of Formulas 1 or 2, as described herein. The compounds of Formulas 1 and 2 are also useful for treating pain, and treating drug addiction, nicotine addiction, and/or obesity. The compounds can exist as individual stereoisomers, racemic mixtures, diastereomers and the like.

Claims17

Dependent claims

A compound of Formula 1 or 2:

wherein k, and p are each 1, m and n are individually 0 or 1;
provided that if m is 1, then n is 0, and if n is 1, then m is 0;
Ar is pyridine, optionally substituted at any position with a substituent Z;
Z is selected from the group consisting of lower alkyl, lower alkenyl, cycloalkyl, phenyl, benzyl, halo, —OR′, —NR′R″, —CF3, —CN, —NO2, ——C≡CR′, —SR′, and —SO2R′;
where R′ and R″ are individually hydrogen, lower alkyl, cycloalkyl phenyl, or benzyl;
and
R is hydrogen, unsubstituted lower alkyl, unsubstituted arylalkyl, unsubstituted alkoxycarbonyl, or unsubstituted aryloxycarbonyl;
or a pharmaceutically acceptable salt thereof.

5 more elements

Dependencies are inferred from the claim text.

Facts

Application

10/711,969Filed 15 Oct 2004 · us provisional application

Priority

15 Oct 2003

Published

US 2005/0282823 A122 Dec 2005

Granted

22 Jul 2008

Term ends

Not estimatedThe source records don’t support an estimate.

Classification44 codes

C07D 221/22
Condensed with carbocyclic rings or ring systems: bridged ring systems
A61P 1/02
Drugs for disorders of the alimentary tract or the digestive system: stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
A61P 1/04
Drugs for disorders of the alimentary tract or the digestive system: for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of…
A61P 1/16
Drugs for disorders of the alimentary tract or the digestive system: for liver or gallbladder disorders, e.g. hepatoprotective agents,…

Pharmaceutical compositions and methods for relieving pain and treating central nervous system disorders

Life of this patent

Pharmaceutical compositions and methods for relieving pain and treating central nervous system disorders

Life of this patent

Abstract

Claims17