Spiroazacyclic compounds as monoamine receptor modulators

A compound of formula I, salts and stereoisomers thereof:

• wherein X is O;
• Y is selected from the group consisting of O and S;
• Z is CH;
• R1 is selected from the group consisting of hydrogen, optionally substituted substituent selected from the group consisting of C1-6 alkyl, C2-8 alkenyl, C2-8 alkynyl, C3-8 cycloalkyl, aryl, heteroaryl, aryl(C1-6 alkyl), heteroaryl(C1-6 alkyl), heterocyclyl(C1-6 alkyl), hydroxy(C1-6 alkyl), amino(C1-6 alkyl), and halo(C1-6 alkyl);
• wherein the heteroaryl(C1-6 alkyl) is selected from the group consisting of furan(C1-6 alkyl), benzofuran(C1-6 alkyl), thiophene(C1-6 alkyl), benzothiophene(C1-6 alkyl), pyrrole(C1-6 alkyl), pyridine(C1-6 alkyl), oxazole(C1-6 alkyl), benzoxazole(C1-6 alkyl), isoxazole(C1-6 alkyl), benzisoxazole(C1-6 alkyl), thiazole(C1-6 alkyl), benzothiazole(C1-6 alkyl), isothiazole(C1-6 alkyl), imidazole(C1-6 alkyl), benzimidazole(C1-6 alkyl), pyrazole(C1-6 alkyl), indazole(C1-6 alkyl), tetrazole(C1-6 alkyl), furazan(C1-6 alkyl), 1,2,3-oxadiazole(C1-6 alkyl), 1,2,3-thiadiazole(C1-6 alkyl), 1,2,4-thiadiazole(C1-6 alkyl), triazole(C1-6 alkyl), benzotriazole(C1-6 alkyl), quionoline(C1-6 alkyl), isoquinoline(C1-6 alkyl), pyridazine(C1-6 alkyl), pyrimidine(C1-6 alkyl), purine(C1-6 alkyl), pyrazine(C1-6 alkyl), pteridine(C1-6 alkyl), pyrrole(C1-6 alkyl), phenoxazole(C1-6 alkyl), oxazole(C1-6 alkyl), isoxazole(C1-6 alkyl), oxadiazole(C1-6 alkyl), benzopyrazole(C1-6 alkyl), indazole(C1-6 alkyl), quinolizine(C1-6 alkyl), cinnoline(C1-6 alkyl), phthalazine(C1-6 alkyl), quinazoline(C1-6 alkyl), and quinoxaline(C1-6 alkyl);
• m is 0;
• R4 is absent;
• R5 and R6 are independently an optionally substituted substituent selected from the group consisting of aryl(C1-6 alkyl), heteroaryl(C1-6 alkyl), and heterocyclyl(C1-6 alkyl);
• R2 and R3 are independently selected from the group consisting of hydrogen, halogen, hydroxy, and optionally substituted C1-6 alkyl or selected such that R2 and R3 together form a ring system such that
• is selected front the group consisting of
• wherein R7 and R8 are independently selected from the group consisting of hydrogen, halogen, hydroxy, and C1-6 alkyl.