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US 7,402,582 B2Granted
Pyrrolotriazine compounds useful as kinase inhibitors and methods of treating kinase-associated conditions therewith
AssigneeBristol-Myers Squibb Company
InventorsAshvinikumar V. Gavai, Ping Chen, Derek J. Norris
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Abstract
The invention relates to at least one pyrrolotriazine derivative, at least one pharmaceutical composition comprising at least one pyrrolotriazine derivative, and at least one method of using at least one pyrrolotriazine derivative to treat at least one kinase associated condition.
Claims23
A compound of the formula:
- wherein:
- R1 is
- R2 is H, lower alkyl, halogen, or —OR9;
- R3 and R4 are independently H, lower alkyl, substituted lower alkyl, OR10, or NR11R12;
- n is an integer from 2-6;
- R5 and R6 are independently H, alkyl, substituted alkyl, or taken together with the N to which they are attached form a 4 to 7-membered heterocyclic or substituted heterocyclic ring optionally containing at least two heteroatoms;
- R7 and R8 are independently H, alkyl, or substituted alkyl;
- m is an integer from 1-3;
- L is —OC(═O)NH—, —O—, —C(═O)NH—, —NHC(═O)—, or —NHS(═O)2—;
- R9 is H or lower alkyl;
- R10 is H, alkyl, substituted alkyl, alkylamino, or substituted alkylamino;
- R11 and R12 are independently H, alkyl, or substituted alkyl;
- and
- Ar1 and Ar2 are independently aryl, substituted aryl, heteroaryl, or substituted heteroaryl,
- or a pharmaceutically acceptable salt thereof.
12 more elements
Dependencies are inferred from the claim text.